Normal view

Received — 27 May 2026 ⏭ Journals

Nature - Issue - nature.com science feeds
Molecular basis for methylation-sensitive editing by Cas9 Mitchell O. Roth · Yuerong Shu · Yu Zhao · Despoina Trasanidou · Renee D. Hoffman · Christian Südfeld · Eugenios Bouzetos · Nikolaos Trasanidis · Michael Zawrotny · Mary K. Gelasco · Megan L. Medina · Anuska Das · Jay Rai · Hemant N. Goswami · Bing Wang · John van der Oost · Hong Li
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10384-zThermoCas9, a genome-editing enzyme that is sensitive to the DNA methylation status of the target locus, is characterized and shows promise for targeting hypomethylated DNA regions in cancer cells.
15 April 2026 at 08:00

Molecular basis for methylation-sensitive editing by Cas9

Nature - Issue - nature.com science feeds

By: Mitchell O. Roth · Yuerong Shu · Yu Zhao · Despoina Trasanidou · Renee D. Hoffman · Christian Südfeld · Eugenios Bouzetos · Nikolaos Trasanidis · Michael Zawrotny · Mary K. Gelasco · Megan L. Medina · Anuska Das · Jay Rai · Hemant N. Goswami · Bing Wang · John van der Oost · Hong Li

15 April 2026 at 08:00

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10384-z

ThermoCas9, a genome-editing enzyme that is sensitive to the DNA methylation status of the target locus, is characterized and shows promise for targeting hypomethylated DNA regions in cancer cells.

Received — 4 April 2026 ⏭ Journals

Cell
Genetically encoded fluorescent reporters to visualize α-synuclein pathology in live brain Li Zhang · Minhui Yu · Guoqing Chen · Siyuan Ge · Mengdi Wang · Xianying Zhang · Miao Zhao · Huating Gu · Meizhu Huang · Aixue Liu · Gengxin Ran · Zeyuan Liu · Tiepeng Liao · Qi Chen · Chenjian Miao · Yao Lu · Yibing Wang · Fengchao Wang · Zhihui Liu · Hongying Zhu · Qian Wu · Zhuan Zhou · Wei Xiong · Xiaoqun Wang · Peng Cao
The development of genetically encoded fluorescent reporters, along with their corresponding knock-in mouse lines for labeling α-Syn inclusions, enables diverse applications in studying the propagation and pathological effects of α-Syn inclusions in the live brain.
4 March 2026 at 08:00

Genetically encoded fluorescent reporters to visualize α-synuclein pathology in live brain

Cell

By: Li Zhang · Minhui Yu · Guoqing Chen · Siyuan Ge · Mengdi Wang · Xianying Zhang · Miao Zhao · Huating Gu · Meizhu Huang · Aixue Liu · Gengxin Ran · Zeyuan Liu · Tiepeng Liao · Qi Chen · Chenjian Miao · Yao Lu · Yibing Wang · Fengchao Wang · Zhihui Liu · Hongying Zhu · Qian Wu · Zhuan Zhou · Wei Xiong · Xiaoqun Wang · Peng Cao

4 March 2026 at 08:00

The development of genetically encoded fluorescent reporters, along with their corresponding knock-in mouse lines for labeling α-Syn inclusions, enables diverse applications in studying the propagation and pathological effects of α-Syn inclusions in the live brain.