Spatial multi-omics reveals macrophage states that constrain adaptive immunity in immunosuppressed non-melanoma skin cancer.

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10572-xA fungal long non-coding RNA from Magnaporthe oryzae translocates into rice cells to sequester a host microRNA that normally represses PKR1, a negative immunity regulator, thereby facilitating infection and revealing a widespread RNA-based pathogen–host interaction mechanism.

Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10297-xA drawing-like task designed to study compositional generalization identifies a specific neural population in the ventral premotor cortex in primates that encodes action symbols.

Science, Ahead of Print.

Li et al. developed a ferritin aggregation cell engager that helps CAR T cells better recognize and attack leukemia cells without re-engineering the CAR itself. This versatile platform overcomes antigen modulation and enables combination with chemotherapy.

Cell Death Discovery, Published online: 31 March 2026; doi:10.1038/s41420-026-03086-yO-GlcNAcylation of UGDH: emerging insights into immunometabolic regulation and therapeutic implications

npj Digital Medicine, Published online: 30 March 2026; doi:10.1038/s41746-026-02570-0A unified deep learning framework for cross-platform harmonization of multi-tracer PET quantification in neurodegenerative disease

npj Digital Medicine, Published online: 28 March 2026; doi:10.1038/s41746-026-02575-9A multicenter randomized clinical trial of portable transcranial alternating current stimulation for major depressive disorder

Histidine scanning represents a broadly applicable technique for the identification of critical interaction sites within TCRs and other mechanosensory receptors to enhance receptor signaling strength and augment therapeutic efficacy via the catch bond mechanism.