Oncogenesis - nature.com science feeds
CD44v5 promotes triple-negative breast cancer cisplatin resistance by enhancing IL-4/IL-4Rα/STAT3 pathway and stabilizing membranous SLC7A11 Lan Wang · Xinyi Bao · Hongyun Ma · Zhongjian Ji · Jiaren Liu · Meng Jiang · Yanhua Dai · Nan Li · Chun Yang
Oncogenesis, Published online: 21 August 2026; doi:10.1038/s41389-026-00650-0CD44v5 promotes triple-negative breast cancer cisplatin resistance by enhancing IL-4/IL-4Rα/STAT3 pathway and stabilizing membranous SLC7A11
21 August 2026 at 08:00

STAT3 pathway and stabilizing membranous SLC7A11

By: Lan Wang · Xinyi Bao · Hongyun Ma · Zhongjian Ji · Jiaren Liu · Meng Jiang · Yanhua Dai · Nan Li · Chun Yang

21 August 2026 at 08:00

Oncogenesis, Published online: 21 August 2026; doi:10.1038/s41389-026-00650-0

Cell
A bivalent molecular glue linking lysine acetyltransferases to oncogene-induced cell death Meredith N. Nix · Sai Gourisankar · Kevin J. Bowman · Sabin A. Nettles · Haopeng Yang · Brendan G. Dwyer · Roman C. Sarott · Hind Abuzaid · Michael M. Martinez · Nick Phillips · Vincent Cabaud · Artur Hakobyan · Vahram Arakelov · Garik Petrosyan · Aram Davtyan · Yanlan Wang · Juste M. Simanauskaite · Bryan A. Romero · Hannah M. Jones · Andrey Krokhotin · Tara N. Lowensohn · Lei Chen · Cara Low · Hannes Vogel · Mark M. Davis · Daniel Fernandez · Tinghu Zhang · Michael R. Green · Stephen M. Hinshaw · Nathanael S. Gray · Gerald R. Crabtree
Chemically induced proximity of lysine acetyltransferases (KATs) with BCL6 reprograms epigenetic signaling to eliminate lymphoma tumors. Structural and mechanistic studies demonstrate that fortuitous protein-protein contacts convert proximity induction into targeted changes in chromatin, revealing a key mechanism by which small molecules can co-opt oncogenic transcriptional regulators to elicit malignant cell death.
20 July 2026 at 08:00

A bivalent molecular glue linking lysine acetyltransferases to oncogene-induced cell death

Cell

By: Meredith N. Nix · Sai Gourisankar · Kevin J. Bowman · Sabin A. Nettles · Haopeng Yang · Brendan G. Dwyer · Roman C. Sarott · Hind Abuzaid · Michael M. Martinez · Nick Phillips · Vincent Cabaud · Artur Hakobyan · Vahram Arakelov · Garik Petrosyan · Aram Davtyan · Yanlan Wang · Juste M. Simanauskaite · Bryan A. Romero · Hannah M. Jones · Andrey Krokhotin · Tara N. Lowensohn · Lei Chen · Cara Low · Hannes Vogel · Mark M. Davis · Daniel Fernandez · Tinghu Zhang · Michael R. Green · Stephen M. Hinshaw · Nathanael S. Gray · Gerald R. Crabtree

20 July 2026 at 08:00

Chemically induced proximity of lysine acetyltransferases (KATs) with BCL6 reprograms epigenetic signaling to eliminate lymphoma tumors. Structural and mechanistic studies demonstrate that fortuitous protein-protein contacts convert proximity induction into targeted changes in chromatin, revealing a key mechanism by which small molecules can co-opt oncogenic transcriptional regulators to elicit malignant cell death.