Cell Death Discovery, Published online: 11 April 2026; doi:10.1038/s41420-026-03118-7TREM2-mediated microglial phagocytosis of inhibitory synapses contributes to prolonged FS-induced epileptogenesis

Nature Cancer, Published online: 03 April 2026; doi:10.1038/s43018-026-01141-2Li et al. present PRET, a few-shot system for pan-cancer detection not requiring model fine-tuning, validated it in multicenter datasets and found that it outperformed existing approaches across tasks and pathologists in lymph node metastasis detection.

Xiao et al. identify α-KG as a rosacea-associated metabolite that activates the OXGR1-Gq-MYL9 axis in the vascular smooth muscle cells to boost contractility and suppress pathological vasodilation underlying erythema. Cryo-EM reveals a bipartite-acid pocket of OXGR1 that enables structure-guided development of A-1, a selective agonist that alleviates erythema in rosacea-like models.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10296-yIn mice, a circuit between the spinal cord and various regions of the brain, centring on spinal-cord-projecting neurons in the rostral ventromedial medulla, has a key role in driving chronic pain.

npj Digital Medicine, Published online: 30 March 2026; doi:10.1038/s41746-026-02570-0A unified deep learning framework for cross-platform harmonization of multi-tracer PET quantification in neurodegenerative disease

Development of an ERAD-hijacking technology overcomes the challenges of current targeted protein degradation approaches to achieve degradation of transmembrane proteins.