Science, Ahead of Print.

npj Digital Medicine, Published online: 31 March 2026; doi:10.1038/s41746-026-02527-3Rapid and noninvasive artificial intelligence-assisted diagnostic method for oral squamous cell carcinoma

β-hydroxybutyrate (BHB), the ketone body associated with a ketogenic diet, metabolically reprograms and fuels CAR T cells to achieve proliferation, cytokine production, and superior tumor control. These findings suggest that BHB supplementation may be a practical way to boost adoptive cancer immunotherapy.

Histidine scanning represents a broadly applicable technique for the identification of critical interaction sites within TCRs and other mechanosensory receptors to enhance receptor signaling strength and augment therapeutic efficacy via the catch bond mechanism.