Cell Death Discovery, Published online: 31 March 2026; doi:10.1038/s41420-026-03086-yO-GlcNAcylation of UGDH: emerging insights into immunometabolic regulation and therapeutic implications

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Histidine scanning represents a broadly applicable technique for the identification of critical interaction sites within TCRs and other mechanosensory receptors to enhance receptor signaling strength and augment therapeutic efficacy via the catch bond mechanism.