Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10310-3
DNA damage burden and inadequate repair in CUX2+ cortical layer 2/3 excitatory neurons contributes to selective vulnerability in neuroinflammatory injury.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10230-2
Dissociative ionization of H2 molecules by the combination of a phase-locked attosecond laser pair and a few-cycle NIR laser shows that ion–photoelectron entanglement influences electronic coherence in H2+, allowing control over the degree of entanglement by varying the delay between the pulses.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10301-4
Longitudinal tracking of mice reveals that stable, specialized social roles emerge spontaneously within groups during a foraging task, with dopaminergic activity in the ventral tegmental area driving sex-divergent patterns of specialization.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10299-9
N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10304-1
Long-range interactions mediated by protein electric dipole moments have a role in driving the assembly and disassembly of super-signalling complex I for promoting NF-κB signalling.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10359-0
LIGO–Virgo–KAGRA’s fourth Gravitational-Wave Transient Catalog shows evidence of a clear pair-instability gap in the distribution of binary black-hole secondary masses but is absent in the larger primary masses.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10290-4
The transcription factor ATF4 is shown to regulate double-stranded DNA repair within vulnerable CUX2+ upper-layer 2/3 cortical neurons, enabling their survival during development.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10203-5
A study of reproducibility in a stratified random sample of 600 papers published from 2009 to 2018 in 62 journals spanning the social and behavioural sciences finds higher reproducibility among more recent papers and papers from journals that require data sharing.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10321-0
Analysis of FeTe films grown using molecular-beam epitaxy and annealed under a Te flux post-growth shows that stoichiometric FeTe is inherently a superconductor, contradicting the long-held view that it is an antiferromagnetic metal.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-025-10078-y
A large-scale study on the replicability of claims from social and behavioural science journals reports that about half of the results replicate in the same patterns as the original study.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10357-2
Superconductivity in twisted bilayer WSe2 evolves smoothly with twist angle and emerges near Fermi surface reconstruction, linking previously distinct phase diagrams and clarifying its correlated origin.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10312-1
The rate of axon ensheathment varies within individual myelinating processes, resulting in chains of myelin sheaths connected by bridges consisting of thin cytoplasmic processes that provide flexibility for myelination of highly branched axons.
Nature, Published online: 01 April 2026; doi:10.1038/s41586-025-09844-9
When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.
npj Digital Medicine, Published online: 31 March 2026; doi:10.1038/s41746-026-02577-7
A randomized trial of a digitally delivered, home-based neuromodulation and mindfulness intervention for pain management in older adults with knee osteoarthritis
Nature Medicine, Published online: 31 March 2026; doi:10.1038/s41591-026-04315-8
Benralizumab (an anti-IL-5 receptor α antibody), compared to placebo, significantly reduced the risk of first flare in patients with hypereosinophilic syndrome.
Nature Biotechnology, Published online: 27 March 2026; doi:10.1038/s41587-026-03074-8
Unpaired data as a first-order challenge in single-cell and spatial proteomics
Nature Biotechnology, Published online: 27 March 2026; doi:10.1038/s41587-026-03046-y
Variant mapping of sorghum promoters identifies CRISPR-accessible mutations that upregulate gene expression.
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10112-7
Genome-wide analysis shows European dogs existed by 14,200 years ago, were already genetically distinct, received less Neolithic Southwest Asian admixture than humans did and contributed substantially to later European dogs.
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10270-8
Single-nucleus chromatin and RNA sequencing identifies epigenetic chromatin domains that confer vulnerability to paediatric brain tumours such as ependymomas, providing insight into the development of such tumours despite ‘quiet’ genomes.
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