Cell
Unified modeling of 3D molecular generation via atomic interactions with PocketXMol Xingang Peng · Ruihan Guo · Fenglin Guo · Ziyi Wang · Jiayu Sun · Jiaqi Guan · Yinjun Jia · Yan Xu · Yanwen Huang · Muhan Zhang · Jian Peng · Xinquan Wang · Chuanhui Han · Zihua Wang · Jianzhu Ma
A versatile, atom-level generative AI model enables unified pocket-interacting tasks, from docking to de novo design, and demonstrates robust experimental validation for both small-molecule and peptide therapeutics.
18 February 2026 at 08:00

Unified modeling of 3D molecular generation via atomic interactions with PocketXMol

Cell

By: Xingang Peng · Ruihan Guo · Fenglin Guo · Ziyi Wang · Jiayu Sun · Jiaqi Guan · Yinjun Jia · Yan Xu · Yanwen Huang · Muhan Zhang · Jian Peng · Xinquan Wang · Chuanhui Han · Zihua Wang · Jianzhu Ma

18 February 2026 at 08:00

A versatile, atom-level generative AI model enables unified pocket-interacting tasks, from docking to de novo design, and demonstrates robust experimental validation for both small-molecule and peptide therapeutics.

Nature - Issue - nature.com science feeds
DNA damage burden causes selective CUX2 neuron loss in neuroinflammation Laura Morcom · Wenlong Xia · Zhaoyang Xu · Yashika Awasthi · Celine Geywitz · Matthew O. Ellis · Tomas Noli · Amel Zulji · Daniel Yamamoto · Gemma C. Girdler · Li Kai · Keying Zhu · Mingming Wei · Xiao-Yan Tang · Kimberly K. Hoi · Julio Gonzalez-Maya · Greg J. Duncan · Adrien M. Vaquie · Diana Gold Diaz · Riki Kawaguchi · Erdong Liu · Yu Sun · Denny Yang · Gregory D. Jordan · I-Ling Lu · Staffan Holmqvist · Theresa Bartels · Katherine Ridley · Jennifer Ja-Yoon Choi · Santos J. Franco · Eric J. Huang · Ben Emery · Daniel Geschwind · Lucas Schirmer · Gabriel Balmus · Brian Popko · Stephen P. J. Fancy · David H. Rowitch
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10310-3DNA damage burden and inadequate repair in CUX2+ cortical layer 2/3 excitatory neurons contributes to selective vulnerability in neuroinflammatory injury.
1 April 2026 at 08:00

DNA damage burden causes selective CUX2 neuron loss in neuroinflammation

Nature - Issue - nature.com science feeds

By: Laura Morcom · Wenlong Xia · Zhaoyang Xu · Yashika Awasthi · Celine Geywitz · Matthew O. Ellis · Tomas Noli · Amel Zulji · Daniel Yamamoto · Gemma C. Girdler · Li Kai · Keying Zhu · Mingming Wei · Xiao-Yan Tang · Kimberly K. Hoi · Julio Gonzalez-Maya · Greg J. Duncan · Adrien M. Vaquie · Diana Gold Diaz · Riki Kawaguchi · Erdong Liu · Yu Sun · Denny Yang · Gregory D. Jordan · I-Ling Lu · Staffan Holmqvist · Theresa Bartels · Katherine Ridley · Jennifer Ja-Yoon Choi · Santos J. Franco · Eric J. Huang · Ben Emery · Daniel Geschwind · Lucas Schirmer · Gabriel Balmus · Brian Popko · Stephen P. J. Fancy · David H. Rowitch

1 April 2026 at 08:00

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10310-3

DNA damage burden and inadequate repair in CUX2+ cortical layer 2/3 excitatory neurons contributes to selective vulnerability in neuroinflammatory injury.

Nature - Issue - nature.com science feeds
Electric dipole moment drives the dynamics of the TNFR1 complex I signalosome Jianping Liu · Jing Zhao · Jiayang Gao · Kun Zhao · Yaoyao Han · Jing Yang · Zefei Li · Jianyu Ye · Ziyu Sun · Fengyi Wang · Xinyi Liu · Zekai Li · Siyu Ji · Bo Liu · Cong Liu · Yixiao Zhang · Junying Yuan · James J. Chou
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10304-1Long-range interactions mediated by protein electric dipole moments have a role in driving the assembly and disassembly of super-signalling complex I for promoting NF-κB signalling.
1 April 2026 at 08:00

Electric dipole moment drives the dynamics of the TNFR1 complex I signalosome

Nature - Issue - nature.com science feeds

By: Jianping Liu · Jing Zhao · Jiayang Gao · Kun Zhao · Yaoyao Han · Jing Yang · Zefei Li · Jianyu Ye · Ziyu Sun · Fengyi Wang · Xinyi Liu · Zekai Li · Siyu Ji · Bo Liu · Cong Liu · Yixiao Zhang · Junying Yuan · James J. Chou

1 April 2026 at 08:00

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10304-1

Long-range interactions mediated by protein electric dipole moments have a role in driving the assembly and disassembly of super-signalling complex I for promoting NF-κB signalling.

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