Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons
17 March 2026 at 08:00
(Cell 188, 6283–6300.e1–e10; October 30, 2025)
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10322-z
Combining single-cell parallel profiling of genome conformation, histone modifications, chromatin accessibility and gene expression reveals dynamics and intranuclear spatial clustering of epigenome profiles, enabling sophisticated analysis of the regulatory landscape across cell types and tissues.