LoginFunctional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons
17 March 2026 at 08:00
(Cell 188, 6283–6300.e1–e10; October 30, 2025)
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Received — 4 April 2026
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Journals
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Cell
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Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons
(Cell 188, 6283–6300.e1–e10; October 30, 2025)
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Efficient amyloid-β degradation in Alzheimer’s disease using SPYTACs
SPYTAC is a synthetic peptide-programmed targeted protein degradation platform harnessing LRP1 to drive lysosomal degradation of extracellular amyloid-β in the brain and periphery. In 5×FAD mice, SPYTAC treatment efficiently degrades amyloid-β, preserves neurons, and improves cognition with reduced neuroinflammation and microhemorrhage when compared with antibody therapy.
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Efficient amyloid-β degradation in Alzheimer’s disease using SPYTACs
4 March 2026 at 08:00
SPYTAC is a synthetic peptide-programmed targeted protein degradation platform harnessing LRP1 to drive lysosomal degradation of extracellular amyloid-β in the brain and periphery. In 5×FAD mice, SPYTAC treatment efficiently degrades amyloid-β, preserves neurons, and improves cognition with reduced neuroinflammation and microhemorrhage when compared with antibody therapy.
Received — 26 March 2026
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Journals
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npj Digital Medicine
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WiseMind: a knowledge-guided multi-agent framework for accurate and empathetic psychiatric diagnosis
npj Digital Medicine, Published online: 25 March 2026; doi:10.1038/s41746-026-02559-9WiseMind: a knowledge-guided multi-agent framework for accurate and empathetic psychiatric diagnosis
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WiseMind: a knowledge-guided multi-agent framework for accurate and empathetic psychiatric diagnosis
25 March 2026 at 08:00
npj Digital Medicine, Published online: 25 March 2026; doi:10.1038/s41746-026-02559-9
WiseMind: a knowledge-guided multi-agent framework for accurate and empathetic psychiatric diagnosis