A multi-omic single-cell atlas of the aging mouse brain reveals cell-type-specific transposon methylation changes, strengthening of 3D genome boundaries, and regionally heterogeneous aging signatures. These findings offer a resource to understand the molecular mechanisms of brain aging and guide future research on neurodegeneration.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10221-3Intelligent and miniaturized drug delivery devices leveraging advances in biotechnology, artificial intelligence, electronics and materials science enable treatments with increased precision and responsiveness, with applications in cancer, diabetes, cardiovascular disease and other diseases.