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Normal view

Received — 8 April 2026 ⏭ Journals

Zodasiran for cholesterol and triglyceride lowering in patients with hyperlipidemia: final report of phase 1 basket trial

✇Nature Medicine
By: Gerald F. Watts · Russell Scott · David Sullivan · John Baker · Peter Clifton · James Hamilton · Bruce Given · Stacey Melquist · Rong Zhou · Daniel Gaudet · Ira J. Goldberg · Joshua W. Knowles · Nicholas J. Leeper · Robert A. Hegele · Christie M. Ballantyne
7 April 2026 at 08:00

Nature Medicine, Published online: 07 April 2026; doi:10.1038/s41591-026-04307-8

In a phase 1 basket trial, the small interfering RNA zodasiran, targeting ANGPTL3, lowered triglycerides in patients with severe hypertriglyceridemia and lowered both triglycerides and low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolemia.

Isatuximab, carfilzomib, lenalidomide and dexamethasone in newly diagnosed multiple myeloma: a randomized phase 3 trial

✇Nature Medicine
By: Francesca Gay · Wilfried Roeloffzen · Meletios A. Dimopoulos · Laura Rosiñol · Marjolein van der Klift · Roberto Mina · Albert Oriol · Eirini Katodritou · Ka Lung Wu · Paula Rodríguez Otero · Roman Hájek · Elisabetta Antonioli · Mark van Duin · Mattia D’Agostino · Joaquín Martínez-López · Elena M. van Leeuwen-Segarceanu · Elena Zamagni · Niels W. C. J. van de Donk · Katja C. Weisel · Luděk Pour · Jakub Radocha · Angelo Belotti · Fredrik Schjesvold · Joan Bladé · Hermann Einsele · Pieter Sonneveld · Mario Boccadoro · Annemiek Broijl
6 April 2026 at 08:00

Nature Medicine, Published online: 06 April 2026; doi:10.1038/s41591-026-04282-0

In the phase 3 EMN24 IsKia trial, transplant-eligible patients with newly diagnosed multiple myeloma who received isatuximab with carfilzomib, lenalidomide and dexamethasone pretransplant induction and post-transplant consolidation showed higher rates of measurable residual disease negativity after consolidation than patients who received carfilzomib, lenalidomide and dexamethasone.

An international mega-analysis of psychedelic drug effects on brain circuit function

✇Nature Medicine
By: Manesh Girn · Manoj K. Doss · Leor Roseman · Katrin H. Preller · Fernanda Palhano-Fontes · Lorenzo Pasquini · Frederick S. Barrett · Pablo Mallaroni · Natasha L. Mason · Christopher Timmermann · Drummond E. McCulloch · Patrick M. Fisher · Brian S. Winston · Flora Moujaes · Felix Muller · Matthias E. Liechti · Franz X. Vollenweider · Johannes G. Ramaekers · Kim Kuypers · Draulio B. Araujo · Olaf Sporns · Joshua Siegel · Nico Dosenbach · David J. Nutt · Robin L. Carhart-Harris · Emmanuel A. Stamatakis · Danilo Bzdok
6 April 2026 at 08:00

Nature Medicine, Published online: 06 April 2026; doi:10.1038/s41591-026-04287-9

Analysis of neuroimaging datasets across five major psychedelics revealed a shared brain signature and provides a comprehensive insight into how these drugs reorganize brain architecture.

Towards a physics informed digital twin to predict cerebral blood flow and cerebral vascular regulation

✇npj Digital Medicine
By: Jennifer K. Briggs · J. N. Stroh · Soojin Park · Brandon Foreman · Michael M. Tymko · Jay Carr · Melike Sirlanci · Philip N. Ainslie · Richard K. P. Benninger · Tellen D. Bennett · David J. Albers
6 April 2026 at 08:00

npj Digital Medicine, Published online: 06 April 2026; doi:10.1038/s41746-026-02600-x

Towards a physics informed digital twin to predict cerebral blood flow and cerebral vascular regulation
Received — 4 April 2026 ⏭ Journals

Target product profiles for treatments to delay or prevent symptomatic Alzheimer’s disease

✇Nature Medicine
By: Jeffrey L. Cummings · Michael G. Agadjanyan · Maureen Barry · Lawrence Corey · Rachelle Doody · Suzanne Hendrix · Soeren Mattke · Niklas Mattsson-Carlgren · Eric McDade · Joseph P. Menetski · Richard C. Mohs · Katherine A. Partrick · Nikolai Petrovsky · Dennis J. Selkoe · Diego Silva · Reisa A. Sperling · Benjamin Tiede · George Vradenburg
3 April 2026 at 08:00

Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04305-w

To accelerate therapeutic development and equip stakeholders with clear benchmarks, the authors outline target product profiles for therapies designed to delay or prevent the onset of clinical symptoms of Alzheimer’s disease.

Single-cell and spatial profiling in cancer biology and clinical oncology

✇Nature Cancer
By: Chris J. Frangieh · Joy Linyue Fan · Johannes C. Melms · Parin Shah · Elham Azizi · Benjamin Izar
3 April 2026 at 08:00

Nature Cancer, Published online: 03 April 2026; doi:10.1038/s43018-026-01142-1

Izar and colleagues review the insights into cancer biology gained via single-cell analyses and spatial profiling and overview the challenges and opportunities associated with the implementation of these approaches to guide clinical discovery.

Semaglutide on liver fibrosis and heart outcomes in patients at high risk of liver fibrosis: a prespecified analysis of the SELECT randomized trial

✇Nature Medicine
By: Sebastian M. Meyhöfer · Bertrand Cariou · Cintia Cercato · Helen M. Colhoun · John Deanfield · Michelle T. Long · Ole Kleist Jeppesen · A. Michael Lincoff · Ildiko Lingvay · Jorge Plutzky · Philip N. Newsome · Stephen J. Nicholls · Maria Quiroga · Ferruccio Santini · Arun J. Sanyal · Steven E. Kahn · Donna H. Ryan · Scott S. Emerson · Robert F. Kushner · Kirstine Brown-Frandsen · G. Kees Hovingh · Søren Hardt-Lindberg · Christoffer W. Tornøe
2 April 2026 at 08:00

Nature Medicine, Published online: 02 April 2026; doi:10.1038/s41591-026-04281-1

A prespecified analysis from the SELECT trial showed that semaglutide reduces major adverse cardiovascular events by 20% compared with placebo, particularly in patients at high risk of fibrosis, as indicated by the Fibrosis-4 index.

The E3-ome gene-centric compendium reveals the human E3 ligase landscape

✇Cell
By: Ngee Kiat Chua · Tania J. González-Robles · Cameron J. Reddington · Jane Dudley-Fraser · Richard W. Birkinshaw · Jiru Han · Ashleigh Solano · Soon Wei Wong · Tomasz Kochańczyk · Joshua J. Peter · Mark A. Nakasone · Florian Aust · Jacob Munro · Yeh Huei Tong · Julie Iskander · Waruni Abeysekera · Alex Garnham · Hannah Huckstep · Matthew E. Ritchie · Ingrid Wertz · Sarah Hymowitz · Sharad Kumar · Ron C. Conaway · Gilbert G. Privé · Alex N. Bullock · Jeffrey J. Babon · Rachel E. Klevit · Sonja Lorenz · Alessio Ciulli · Eric S. Fischer · Nicolas H. Thomä · Radosław P. Nowak · Brenda A. Schulman · Michael Rapé · Katrin Rittinger · Julia K. Pagan · Melanie Bahlo · Joel P. Mackay · Peter D. Mace · Christopher D. Lima · Ronald T. Hay · David Komander · Bernhard C. Lechtenberg · Claudio A.P. Joazeiro · Michele Pagano · Kay Hofmann · Rebecca Feltham
20 March 2026 at 08:00
The E3-ome defines the human repertoire of ubiquitin E3 ligases, creating a unified resource that maps their diversity across the ubiquitin and ubiquitin-like systems. By consolidating fragmented knowledge, this framework provides a foundation for studying ubiquitin signaling and accelerating discovery.

Large-scale proteomics across neurological disorders uncovers biomarker panel and targets in multiple sclerosis

✇Cell
By: Jakob Maximilian Bader · Christine Makarov · Sabrina Richter · Maximilian Thomas Strauss · Friederike Held · Maria Wahle · Michael Baggio Lorenz · Lara Pöschl · Patricia Skowronek · Marvin Thielert · Achim Berthele · Wen-Feng Zeng · Constantin Ammar · Isabell Bludau · Benjamin Schubert · Fabian J. Theis · Christiane Gasperi · Bernhard Hemmer · Matthias Mann
25 February 2026 at 08:00
Deep proteome profiling of over 5,000 cerebrospinal fluid samples by mass spectrometry maps protein alterations across major neurological disorders, resolving key sources of variation as well as shared and disease-specific signatures. This framework yields a 22-protein assay that improves the differential diagnosis of multiple sclerosis from other inflammatory conditions, particularly in diagnostically challenging oligoclonal band-negative individuals.
Received — 2 April 2026 ⏭ Journals

DNA damage burden causes selective CUX2 neuron loss in neuroinflammation

✇Nature - Issue - nature.com science feeds
By: Laura Morcom · Wenlong Xia · Zhaoyang Xu · Yashika Awasthi · Celine Geywitz · Matthew O. Ellis · Tomas Noli · Amel Zulji · Daniel Yamamoto · Gemma C. Girdler · Li Kai · Keying Zhu · Mingming Wei · Xiao-Yan Tang · Kimberly K. Hoi · Julio Gonzalez-Maya · Greg J. Duncan · Adrien M. Vaquie · Diana Gold Diaz · Riki Kawaguchi · Erdong Liu · Yu Sun · Denny Yang · Gregory D. Jordan · I-Ling Lu · Staffan Holmqvist · Theresa Bartels · Katherine Ridley · Jennifer Ja-Yoon Choi · Santos J. Franco · Eric J. Huang · Ben Emery · Daniel Geschwind · Lucas Schirmer · Gabriel Balmus · Brian Popko · Stephen P. J. Fancy · David H. Rowitch
1 April 2026 at 08:00

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10310-3

DNA damage burden and inadequate repair in CUX2+ cortical layer 2/3 excitatory neurons contributes to selective vulnerability in neuroinflammatory injury.

Entanglement and electronic coherence in attosecond molecular photoionization

✇Nature - Issue - nature.com science feeds
By: L.-M. Koll · A. J. Suñer-Rubio · T. Witting · R. Y. Bello · A. Palacios · F. Martín · M. J. J. Vrakking
1 April 2026 at 08:00

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10230-2

Dissociative ionization of H2 molecules by the combination of a phase-locked attosecond laser pair and a few-cycle NIR laser shows that ion–photoelectron entanglement influences electronic coherence in H2+, allowing control over the degree of entanglement by varying the delay between the pulses.

Dopaminergic mechanisms of dynamical social specialization

✇Nature - Issue - nature.com science feeds
By: C. Solié · A. Nicolson · R. Justo · Y. Layadi · B. Morin · C. Batifol · L. M. Reynolds · T. Le Borgne · S. L. Fayad · A. Gulmez · Y. Rodriguez Quevedo · J. Allegret-Vautrot · G. Centene Guglielmi · F. de Chaumont · S. Didienne · N. Debray · J.-P. Hardelin · B. Girard · A. Mourot · J. Naudé · C. Viollet · F. Marti · B. Delord · Ph. Faure
1 April 2026 at 08:00

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10301-4

Longitudinal tracking of mice reveals that stable, specialized social roles emerge spontaneously within groups during a foraging task, with dopaminergic activity in the ventral tegmental area driving sex-divergent patterns of specialization.

A µ-opioid receptor superagonist analgesic with minimal adverse effects

✇Nature - Issue - nature.com science feeds
By: Juan L. Gomez · Emilya N. Ventriglia · Zachary J. Frangos · Agnieszka Sulima · Michael J. Robertson · Michael D. Sacco · Reece C. Budinich · Ilinca M. Giosan · Tongzhen Xie · Oscar Solis · Anna E. Tischer · Jennifer M. Bossert · Kiera E. Caldwell · Hannah Bonbrest · Amelie Essmann · Zelai M. Garçon-Poca · Shinbe Choi · Michael R. Noya · Feonil Limiac · Ali Arce · Grant C. Glatfelter · Margaret Robinson · Li Chen · Angelina A. Mullarkey · Dain R. Brademan · Garrett Enten · William Dunne · César Quiroz · Ingrid Schoenborn · Chae Bin Lee · Rana Rais · Daniel P. Holt · Robert F. Dannals · Lei Shi · Ruth Hüttenhain · Sergi Ferré · Eugene Kiyatkin · Jordi Bonaventura · Yavin Shaham · Venetia Zachariou · Michael H. Baumann · Georgios Skiniotis · Kenner C. Rice · Michael Michaelides
1 April 2026 at 08:00

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10299-9

N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.

Electric dipole moment drives the dynamics of the TNFR1 complex I signalosome

✇Nature - Issue - nature.com science feeds
By: Jianping Liu · Jing Zhao · Jiayang Gao · Kun Zhao · Yaoyao Han · Jing Yang · Zefei Li · Jianyu Ye · Ziyu Sun · Fengyi Wang · Xinyi Liu · Zekai Li · Siyu Ji · Bo Liu · Cong Liu · Yixiao Zhang · Junying Yuan · James J. Chou
1 April 2026 at 08:00

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10304-1

Long-range interactions mediated by protein electric dipole moments have a role in driving the assembly and disassembly of super-signalling complex I for promoting NF-κB signalling.

Evidence of the pair-instability gap from black-hole masses

✇Nature - Issue - nature.com science feeds
By: Hui Tong · Maya Fishbach · Eric Thrane · Matthew Mould · Thomas A. Callister · Amanda M. Farah · Nir Guttman · Sharan Banagiri · Daniel Beltran-Martinez · Ben Farr · Shanika Galaudage · Jaxen Godfrey · Jack Heinzel · Marios Kalomenopoulos · Simona J. Miller · Aditya Vijaykumar
1 April 2026 at 08:00

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10359-0

LIGO–Virgo–KAGRA’s fourth Gravitational-Wave Transient Catalog shows evidence of a clear pair-instability gap in the distribution of binary black-hole secondary masses but is absent in the larger primary masses.

Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair

✇Nature - Issue - nature.com science feeds
By: Wenlong Xia · Laura Morcom · Zhaoyang Xu · I-Ling Lu · Qing Wang · Kimberly K. Hoi · Mingming Wei · Keying Zhu · Gregory Jordan · Xiao-Yan Tang · Julio Gonzalez-Maya · Vanesa S. Mattera · Sophia M. Panigrahi · Riki Kawaguchi · Ben Emery · Santos J. Franco · Daniel H. Geschwind · Brian Popko · David H. Rowitch · Stephen P. J. Fancy
1 April 2026 at 08:00

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10290-4

The transcription factor ATF4 is shown to regulate double-stranded DNA repair within vulnerable CUX2+ upper-layer 2/3 cortical neurons, enabling their survival during development.

Investigating the reproducibility of the social and behavioural sciences

✇Nature - Issue - nature.com science feeds
By: Olivia Miske · Anna Lou Abatayo · Mason Daley · Mirka Dirzo · Nicholas Fox · Noah Haber · Krystal M. Hahn · Melissa Kline Struhl · Brinna Mawhinney · Priya Silverstein · Theresa Stankov · Andrew H. Tyner · Matúš Adamkovič · Shilaan Alzahawi · Saule Anafinova · Eli Awtrey · Erick Axxe · James Bailey · Bert N. Bakker · Akshaya Balaji · Gabriel Banik · František Bartoš · Henk Berkman · Zachariah Berry · Felix S. Bethke · Timothy F. Brady · Nate Breznau · Sara Capitan · Tabaré Capitán · Laura Caquelin · Kent Jason Cheng · William J. Chopik · Gwen-Jiro Clochard · Tom Coupé · Jamie Cummins · Elif Gizem Demirag Burak · Jianhua Duan · Kevin M. Esterling · Thomas R. Evans · Nathan Fiala · James Field · Victor Gay · Jing Geng · Johanna Gereke · Ilka Helene Gleibs · Amélie Gourdon-Kanhukamwe · Dmitry Grigoryev · Nicholas Gunby · Paul H. P. Hanel · Sanghyun Hong · Sean Dae Houlihan · Nick Huntington-Klein · Kamil Izydorczak · Kristin Jankowsky · Kai Jonas · Pavol Kačmár · Hansika Kapoor · Sebastian Karcher · Marta Kołczyńska · David Kretschmer · Ljiljana Lazarevic
1 April 2026 at 08:00

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10203-5

A study of reproducibility in a stratified random sample of 600 papers published from 2009 to 2018 in 62 journals spanning the social and behavioural sciences finds higher reproducibility among more recent papers and papers from journals that require data sharing.
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