Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10264-6Androgen activity in the male embryonic hindbrain prolongs hindbrain differentiation in male individuals and drives sex differences in the incidence and prognosis of posterior fossa type A (PFA) ependymoma, an aggressive childhood brain tumour.

Nature Biotechnology, Published online: 20 March 2026; doi:10.1038/s41587-026-03064-wThis Review discusses the promises and pitfalls of biological AI algorithms and presents a vision for generalist biological artificial intelligence, in which models can perform diverse tasks across biological domains.

LUMI lab is a foundation model-driven self-driving platform that autonomously discovers ionizable lipids for mRNA delivery. Iterative active learning uncovered brominated tails as a potent structural motif that enables efficient and safe pulmonary mRNA delivery.

Cell Death Discovery, Published online: 11 March 2026; doi:10.1038/s41420-026-02990-7MAPK14/SLC7A11/GPX4 axis dysregulation drives podocyte ferroptosis via mediating glycerophospholipid metabolism