Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10316-xA single-cell multiomic atlas of the human maternal–fetal interface across pregnancy reveals cell types, states and spatial niches, developmental tissue architectures and transcriptional programmes, and identifies cell types with roles in pre-eclampsia, spontaneous preterm birth and miscarriage.

Yibo et al. identify protein pyruvylation as a post-translational modification that can modulate immune signaling and host antiviral response.