Background: Patients with tracheal diseases often require long-term follow-up after tracheal device placement, with a risk of adverse events that may lead to emergency care and unplanned interventions. Telemedicine has been proposed as an alternative to in-person follow-up to improve access and continuity of care. Objective: The primary objective of this study was to compare the need for emergency department (ED) visits between telemedicine and in-person groups. Secondary objectives included comparing hospital readmissions, 30-day hospital readmissions, and unplanned interventions between groups. Methods: This retrospective, single-institution study included adult patients with tracheal devices who underwent telemedicine and in-person outpatient clinic visits between 2020 and 2024. To balance the groups, we used 1:1 propensity score matching. We collected demographic and clinical data and evaluated the need for ED visits, hospital readmissions, 30-day hospital readmissions, and unplanned interventions. Kaplan-Meier estimation of time to first ED visit was performed to assess outcomes after outpatient visits. Results: A total of 483 patients (n=277, 57% telemedicine and n=206, 43% in-person) underwent 2487 visits (1258 telemedicine and 1229 in-person). After propensity score matching, 336 patients remained (168 in each group). There were no significant differences in the need for ED visits, hospital readmissions, or unplanned interventions. The telemedicine group had significantly fewer 30-day hospital readmissions (odds ratio 0.38, 95% CI 0.16-0.87; =.02). Kaplan-Meier analysis indicated no statistically significant difference in ED-free visits. Conclusions: Telemedicine follow-up was associated with outcomes comparable to those of in-person follow-up in this cohort of adult patients with tracheal devices, with no evidence of an increased need for ED visits. In the matched analysis, telemedicine was associated with lower odds of 30-day hospital readmission.

Nature Medicine, Published online: 26 May 2026; doi:10.1038/s41591-026-04376-9

In a multicenter phase 2 trial, the fibroblast growth factor receptor inhibitor rogaratinib showed encouraging clinical efficacy in patients with succinate dehydrogenase-deficient gastrointestinal stromal tumors, suggesting a potential new treatment option for this patient population and demonstrating that an epigenetic mechanism of oncogene activation can be successfully targeted with a tyrosine kinase inhibitor.

Multiomics profiling of healthy individuals reveals differences across molecular layers and key pathways related to immune, metabolic, and microbiome-linked processes across ethnicities, while geographic relocation reshapes these networks and influences aging trajectories.

An optogenetic model of accelerated intermittent theta burst stimulation reveals cell type-specific plasticity mechanisms and a key role for a fronto-insular circuit in driving the antidepressant effects of this treatment in humans.

(Cell 188, 4567–4585.e1–e12; August 21, 2025)

npj Digital Medicine, Published online: 10 April 2026; doi:10.1038/s41746-026-02583-9

Predicting bilingual aphasia treatment outcomes using digital twins: a double-blind randomized controlled trial

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10488-6

Author Correction: Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10356-3

A robust composite pair-exchange gate based on controlled interactions of fermionic atoms in an optical superlattice demonstrates high fidelities and long Bell-state lifetimes, marking an important step towards a fully digital fermionic quantum computer.

Nature Medicine, Published online: 06 April 2026; doi:10.1038/s41591-026-04287-9

Analysis of neuroimaging datasets across five major psychedelics revealed a shared brain signature and provides a comprehensive insight into how these drugs reorganize brain architecture.

npj Digital Medicine, Published online: 04 April 2026; doi:10.1038/s41746-026-02596-4

Decipher-MR: a vision-language foundation model for 3D MRI representations

Cell Death Discovery, Published online: 02 April 2026; doi:10.1038/s41420-026-03009-x

Correction: The cytotoxicity of gomesin peptides is mediated by the glycosphingolipid pathway and lipid-cholesterol interactions

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10296-y

In mice, a circuit between the spinal cord and various regions of the brain, centring on spinal-cord-projecting neurons in the rostral ventromedial medulla, has a key role in driving chronic pain.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10303-2

A fully automated methodology based on rubrics capturing a broad range of cognitive and intellectual demands is illustrated using LLMs and tasks, demonstrating a new way to evaluate the capabilities of AI systems and anticipate their performance.

Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10251-x

Robustness checks and reproduction of analyses with existing and updated data based on 110 articles in economics and political science journals with data and code-sharing requirements found high levels of robustness and reproducibility and determined that robustness was not dependent on author characteristics or data availability.

Nature, Published online: 01 April 2026; doi:10.1038/d41586-026-00806-3

Modified nitazenes, opioids 1,000 times stronger than morphine, show remarkably few adverse effects in rodents, renewing the potential of these drugs for pain relief.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10237-9

Extreme global climate outcomes may occur even under moderate 2 °C warming and may turn out to be more extreme than model-averaged projections at 3 °C or 4 °C warming.

Cell Death Discovery, Published online: 24 March 2026; doi:10.1038/s41420-026-03037-7

Autophagy inhibition potentiates the antileukemic effect of FLT3 inhibitors and overcomes resistance in FLT3-ITD acute myeloid leukemia

Human-specific transcriptomic and regulatory features are present in the cerebellum, with ZP2 playing a key role in synapse regulation. ZP2 expression is induced by pontine mossy fibers, leading to decreased synaptic proteins and neuronal activity, which provides insights into the evolutionary development of the human cerebellum.

Science, Ahead of Print.

Nature Medicine, Published online: 11 March 2026; doi:10.1038/s41591-026-04288-8

Author Correction: Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study