Oncogenesis, Published online: 14 September 2026; doi:10.1038/s41389-026-00655-9Acrolein- thioredoxin 1- p38 signaling drives neutrophil-mediated immunosuppression and glioblastoma progression

By selectively targeting peripheral 5-HT2AR without inducing psychedelic effects, a non-brain-penetrant agonist boosts antitumor CD8+ T cell immunity and improves immunotherapy responses in preclinical models of colorectal cancer.