Nature Medicine, Published online: 17 September 2026; doi:10.1038/s41591-026-04646-6
Results of this study show in experimental models and data from patient cohorts that the antiseizure medication levetiracetam is associated with longer survival and reduced tumor growth in diffuse midline glioma, but not hemispheric high-grade glioma, by selectively dampening GABAergic synaptic signaling, independently of its canonical SV2A-mediated primary antiseizure mechanism.
Nature Medicine, Published online: 16 September 2026; doi:10.1038/s41591-026-04625-x
In a prospective study involving 1,785 individuals from four countries, the PANXEON exosome-based biomarker, combined with carbohydrate antigen 19-9 levels, achieves high sensitivity for the detection of early-stage pancreatic cancer.
Nature Medicine, Published online: 15 September 2026; doi:10.1038/s41591-026-04610-4
Two early clinical studies of selective KRASG12D inhibitors show encouraging activity in advanced cancers with G12D mutations, signaling a transformative change in the treatment landscape for RAS-driven cancers with potential applications across tumor types and stages of disease.
Nature Medicine, Published online: 15 September 2026; doi:10.1038/s41591-026-04644-8
In the phase 2 RIO trial, there was delayed viral rebound and resistance to broadly neutralizing antibodies 3BNC117-LS and 10-1074-LS in adult males living with HIV undergoing analytical treatment interruption, and initial reservoir sensitivity to autologous antibodies was associated with a longer time to rebound.
npj Digital Medicine, Published online: 14 September 2026; doi:10.1038/s41746-026-03225-w
Data-driven identification of repurposable drugs for ALS
Cell Death Discovery, Published online: 09 September 2026; doi:10.1038/s41420-026-03332-3
Multi-omic profiling reveals metabolic vulnerabilities in enzalutamide resistant prostate cancer
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10954-1
A specific population of macrophages that express high levels of the enzyme PLA2G2D in tumour-draining lymph nodes is associated with poor prognosis in patients, and inhibiting PLA2G2D improves anti-tumour immunity in mouse models.
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10979-6
An imaging system developed to record cellular activity throughout the whole body of zebrafish captures cellular organ dynamics and identifies multiple distributed circuits.
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10998-3
TRI-611 induces the degradation of ALK fusion proteins via a previously undescribed CRBN recruitment motif, and its preclinical anti-tumour activity highlights TRI-611 as a potential new way of treating ALK-positive non-small-cell lung cancer.
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10468-w
Eight integrated mutational footprints collectively explain the mutational processes in 85% of primary prostate cancer genomes.
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10993-8
TM184C—an ancient G-protein-coupled receptor-like superdark protein involved in regulation of autophagy, intercellular connectivity and material exchange—underscores the promise of exploring the understudied human proteome and beyond.
Nature Medicine, Published online: 09 September 2026; doi:10.1038/s41591-026-04647-5
Consensus framework for the validation of generative AI: call for collaborators on the Validation Accords
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