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Received — 14 March 2026 ⏭ Journals

Nature - Issue - nature.com science feeds
Snapshots of the dynamic basis of NTSR1 G protein subtype promiscuity Alina A. Vo · Arnab Modak · Sumin Lu · Scott C. Blanchard · Nevin A. Lambert · Michael J. Robertson
Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10120-7Time-resolved cryo-electron microscopy during activation of Gαi1βγ and Gα11βγ heterotrimers bound to NTSR1 enables isolation of multiple transient complexes along the activation pathway and reveals structural motifs that stabilize these intermediates.
11 March 2026 at 08:00

Snapshots of the dynamic basis of NTSR1 G protein subtype promiscuity

Nature - Issue - nature.com science feeds

By: Alina A. Vo · Arnab Modak · Sumin Lu · Scott C. Blanchard · Nevin A. Lambert · Michael J. Robertson

11 March 2026 at 08:00

Nature, Published online: 11 March 2026; doi:10.1038/s41586-026-10120-7

Time-resolved cryo-electron microscopy during activation of Gαi1βγ and Gα11βγ heterotrimers bound to NTSR1 enables isolation of multiple transient complexes along the activation pathway and reveals structural motifs that stabilize these intermediates.