Background: The targeted application and design of digital health interventions (DHIs) require an understanding of usage determinants. Usage includes uptake (initial use) and frequency (extent of use), but it is unclear whether both components are driven by the same determinants. Objective: This study aimed to examine the determinants of uptake and frequency of use and assess whether they differ. Methods: The investigated DHI was a web portal provided in an intervention for improving disease-related self-management. This study is a secondary analysis of intervention group data from a parallel-group randomized controlled trial. Eligibility criteria were being an adult and being diagnosed with type 2 diabetes and/or coronary heart disease. Sociodemographic, psychological, and health-related variables were examined as determinants. Determinants were analyzed using simple and multiple regression models. Uptake was analyzed using logistic regression, and frequency was analyzed using negative binomial regression with robust SEs. Frequency was analyzed for those who used the DHI at least once. Except for sociodemographic variables, all other variables were standardized to a range from 0 to 1. For simple regression, inflation of the α error due to multiple testing was controlled via the approach of Benjamini and Hochberg, and for multiple regression, it was controlled via the significance of the complete multiple regression model. Results: Of 462 intervention group members, 199 (43.1%) used the web portal at least once. After controlling for inflation of the α error, simple regression for uptake yielded significant effects for higher education (B=0.56, 95% CI 0.18-0.95; =.004), openness (B=1.08, 95% CI 0.33-1.83; =.005), intention regarding physical activity (B=2.28, 95% CI 1.30-3.26;

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10112-7

Genome-wide analysis shows European dogs existed by 14,200 years ago, were already genetically distinct, received less Neolithic Southwest Asian admixture than humans did and contributed substantially to later European dogs.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10266-4

Insights into the mechanism by which phosphatidylserine functions as a non-classical inhibitory molecule during T cell exhaustion, and how phosphatidylserine-targeting antibodies enhance T cell responses are explored.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10306-z

A study in Drosophilareveals a mechanism of non-homeostatic hunger and its critical relevance for memory consolidation.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10231-1

Starburst galaxies are seen to host galaxy-scale winds, which are super-fast and could be powered entirely by the thermal pressure of gas heated by supernovae.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10264-6

Androgen activity in the male embryonic hindbrain prolongs hindbrain differentiation in male individuals and drives sex differences in the incidence and prognosis of posterior fossa type A (PFA) ependymoma, an aggressive childhood brain tumour.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10267-3

Face cells in the macaque inferotemporal cortex are initially able to detect faces and then rapidly switch to a face-specific neural code to discriminate between different face identities.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10170-x

Analysis of nuclear and mitochondrial genomes from archaeological canid remains found across Europe and Anatolia shows that a genetically homogeneous dog population was already widely distributed across the region by 15,000 years ago.

Nature Medicine, Published online: 25 March 2026; doi:10.1038/s41591-026-04299-5

Results of the phase 2 POLAR trial show that biomarker-guided treatment in patients with metastatic pancreatic cancer based on homologous repair deficiency leads to encouraging clinical response rates in immune cell-infiltrated tumors.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10300-5

At present, only 13.4% of the global land surface meets the World Meteorological Organization requirements for annual precipitation monitoring.

Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10336-7

Sedimentary time-series data of Lake Yoa in Chad covering the past 10.25 thousand years (kyr) show that the mid-Holocene African Humid Period experienced several decadal-scale droughts, caused by sudden inputs of freshwater into the North Atlantic.

Nature Cancer, Published online: 25 March 2026; doi:10.1038/s43018-026-01136-z

Czernilofsky et al. identified factors that reprogram stromal cells into an inflammatory, dysfunctional state, leading to the structural disorganization of lymph nodes in B cell lymphoma at single-cell and spatial resolutions.

Nature Medicine, Published online: 24 March 2026; doi:10.1038/s41591-026-04262-4

The first-in-human clinical trial of the LRRK2-targeting antisense oligonucleotide BIIB094 in Parkinson’s disease demonstrates that the treatment is well tolerated and produces dose-dependent reductions in cerebrospinal fluid levels of LRRK2 and phosphorylated Rab10, indicating successful target engagement.

Cell Death Discovery, Published online: 24 March 2026; doi:10.1038/s41420-026-03038-6

Polyethylene nano- and microplastics trigger metabolic stress responses in human vaginal epithelial cells

Cell Death Discovery, Published online: 24 March 2026; doi:10.1038/s41420-026-03058-2

Salinomycin as a death switch: how gastric cancer cells choose their demise

npj Digital Medicine, Published online: 24 March 2026; doi:10.1038/s41746-026-02424-9

Evaluating eRAMP telecare for diabetes in outpatient clinics: a hybrid effectiveness-implementation study

Nature, Published online: 24 March 2026; doi:10.1038/s41586-026-10403-z

Author Correction: 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis

Nature Biotechnology, Published online: 20 March 2026; doi:10.1038/s41587-026-03043-1

A tissue-engineered esophageal segment is functional in minipigs.

Leigh syndrome is a severe and untreatable mitochondrial disease. Using patient-derived models in 2D and 3D, Zink and colleagues identify the PDE5 inhibitor sildenafil as a repurposable drug candidate, leading to lifespan extension in mammalian models and clinical improvement in six individuals with Leigh syndrome.

β-hydroxybutyrate (BHB), the ketone body associated with a ketogenic diet, metabolically reprograms and fuels CAR T cells to achieve proliferation, cytokine production, and superior tumor control. These findings suggest that BHB supplementation may be a practical way to boost adoptive cancer immunotherapy.