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Received — 27 May 2026 ⏭ Journals

Cell Death Discovery nature.com science feeds
Activation of methionine metabolism mediated by HNF4α confers ferroptosis resistance in hepatocellular carcinoma Xiaolei Zhou · Zhenzhen Li · Libo Wang · Yongdeng Xu · Pinsheng Han · TianYu Zhao · Sen Liu · Liuyang Zhu · Miao Zhang · Chenglong Chu · Xiulin Yi · Fengying Yan · Tao Cui · Xiaoliang Wang · Ze Wang
Cell Death Discovery, Published online: 26 May 2026; doi:10.1038/s41420-026-03165-0Activation of methionine metabolism mediated by HNF4α confers ferroptosis resistance in hepatocellular carcinoma
26 May 2026 at 08:00

Activation of methionine metabolism mediated by HNF4α confers ferroptosis resistance in hepatocellular carcinoma

Cell Death Discovery nature.com science feeds

By: Xiaolei Zhou · Zhenzhen Li · Libo Wang · Yongdeng Xu · Pinsheng Han · TianYu Zhao · Sen Liu · Liuyang Zhu · Miao Zhang · Chenglong Chu · Xiulin Yi · Fengying Yan · Tao Cui · Xiaoliang Wang · Ze Wang

26 May 2026 at 08:00

Cell Death Discovery, Published online: 26 May 2026; doi:10.1038/s41420-026-03165-0

Activation of methionine metabolism mediated by HNF4α confers ferroptosis resistance in hepatocellular carcinoma

Nature Cancer
CD300ld on pathologically activated neutrophils promotes tumor immune suppression by binding phosphatidylserine on CD8<sup>+</sup> T cells Chaoxiong Wang · Peixuan Zheng · Anhui Wang · Xinrui Fan · Tianxiang Li · Jingjing Hong · Runze Wang · Chunyan Zhang · Chaogui Luo · Weiwei Yang · Dong Gao · Adili Salai · Min Luo · Zhigang Lu · Dianfan Li · Moubin Lin · Jiayin Peng · Guohui Li · Shuo Han · Yun Zhao
Nature Cancer, Published online: 15 May 2026; doi:10.1038/s43018-026-01169-4Zhao and colleagues show that CD300ld, upregulated in pathologically activated neutrophils, mediates contact-dependent suppression of cytotoxic CD8+ T cells by binding to phosphatidylserine, inhibiting antitumor immune responses.
15 May 2026 at 08:00

CD300ld on pathologically activated neutrophils promotes tumor immune suppression by binding phosphatidylserine on CD8<sup>+</sup> T cells

Nature Cancer

By: Chaoxiong Wang · Peixuan Zheng · Anhui Wang · Xinrui Fan · Tianxiang Li · Jingjing Hong · Runze Wang · Chunyan Zhang · Chaogui Luo · Weiwei Yang · Dong Gao · Adili Salai · Min Luo · Zhigang Lu · Dianfan Li · Moubin Lin · Jiayin Peng · Guohui Li · Shuo Han · Yun Zhao

15 May 2026 at 08:00

Nature Cancer, Published online: 15 May 2026; doi:10.1038/s43018-026-01169-4

Zhao and colleagues show that CD300ld, upregulated in pathologically activated neutrophils, mediates contact-dependent suppression of cytotoxic CD8+ T cells by binding to phosphatidylserine, inhibiting antitumor immune responses.