Nature Nanotechnology, Published online: 14 September 2026; doi:10.1038/s41565-026-02278-y

Thermally assisted intaglio transfer printing and interfacial ligand engineering turn quantum dots into stretchable, ultrabright and high-definition displays.

Nature Nanotechnology, Published online: 14 September 2026; doi:10.1038/s41565-026-02272-4

Innovative ligand engineering and thermally assisted intaglio transfer printing enhance charge injection and pixel resolution in stretchable quantum-dot light-emitting diodes, achieving high efficiencies and luminance while maintaining mechanical integrity under deformation.

Nature Nanotechnology, Published online: 14 September 2026; doi:10.1038/s41565-026-02254-6

This work demonstrates a parallelized four-qubit entangling gate on a room-temperature spin register, and it operates ten times faster than sequences of two-qubit gates with reduced errors.

Nature Nanotechnology, Published online: 14 September 2026; doi:10.1038/s41565-026-02281-3

This study demonstrates on-chip all-optical switching by integrating magnetic memory elements with photonic circuits, establishing a route towards fully integrated magneto-photonic systems for ultrafast and energy-efficient information technologies.

Nature Biomedical Engineering, Published online: 11 September 2026; doi:10.1038/s41551-026-01789-2

Advances in three-dimensional endometrial in vitro models are providing physiologically relevant systems to investigate embryo implantation, tissue remodelling and reproductive disorders, expanding our toolbox for supporting women’s health.

Nature Biomedical Engineering, Published online: 11 September 2026; doi:10.1038/s41551-026-01787-4

Applying extensive chemical modifications to RNA motifs substantially enhances prime editing efficiency in vivo and can be applied for improved efficiencies across RNA-based editing systems.

Nature Nanotechnology, Published online: 10 September 2026; doi:10.1038/s41565-026-02295-x

Author Correction: Half-wave nanolasers and intracellular plasmonic lasing particles

Bispecific antibodies pairing a shared 4-1BB epitope with non-overlapping HER2 epitopes drove HER2-dependent 4-1BB clustering, amplifying T-cell activation and tumor growth inhibition. In vivo, this pairing enhanced antitumor efficacy and tumor infiltration, while reducing systemic inflammation compared to urelumab - establishing a generalizable strategy for TNFRSF-targeted immunotherapy.

Nature Biomedical Engineering, Published online: 10 September 2026; doi:10.1038/s41551-026-01810-8

Author Correction: Radiotherapy-triggered reduction of platinum-based chemotherapeutic prodrugs in tumours

Shim and colleagues develop DLMEH, a metabolically stabilized D-leucine prodrug that bypasses first-pass catabolism. DLMEH activates Sestrin2-dependent mTORC1 signaling, restoring muscle protein synthesis in dexamethasone-induced atrophy. In rat models, DLMEH preserves muscle mass, strength, and endurance superior to L-leucine, supporting DLMEH as a first-in-class candidate for sarcopenia.

Koo and colleagues demonstrate that Un1Cas12f1 recognizes an expanded PAMs, and enables multiplexed genome editing from a single CRISPR array. Delivered as an all-in-one AAV, this compact Un1Cas12f1 system excises Dmd exon 23 in vivo, restores the reading frame and dystrophin expression in a mouse model of Duchenne muscular dystrophy.

Pathogenic variants in the gene encoding 6-pyruvoyl-tetrahydropterin synthase cause primary BH4 deficiency (PBD), leading to hyperphenylalaninemia and reduced monoamine neurotransmitter synthesis. This phase 1/2 study in eight patients with PBD found that sepiapterin increased blood BH4 and rapidly normalized blood phenylalanine levels, with no dose-limiting toxicity or dose-related adverse events.

The recent FDA approval of OTOF gene therapy is a major milestone for the field of hearing loss.1 However, auditory gene therapy still lags behind other fields in terms of clinical trials and approvals. A myriad of promising preclinical studies have been published for pediatric and juvenile-onset hearing loss, but far fewer have demonstrated similar promise for adult-onset hearing disorders. One thing is clear: effective gene delivery to adult hair cells and spiral ganglion neurons remains a key challenge for translating gene therapies for sensorineural hearing loss.

Recombinant AAV gene therapies deliver durable clinical benefit but face immune-mediated challenges that vary by vector, dose, route, and patient. Gulve and colleagues synthesize the clinical manifestations, temporal patterns, and mechanisms of rAAV immunogenicity, highlighting risk assessment and emerging mitigation strategies to support safer, more effective gene therapy development.

Infusion-related reactions (IRRs) can occur with AAV gene therapy. IRRs were observed in two participants who received AAV8 gene therapy and in one who received AAV9 gene therapy. AAV gene therapy IRRs may be rate-related, possibly driven by complement activation. In our studies, a slow, staged infusion mitigated additional IRRs.

Transduction efficiency is a critical determinant of CAR T-cell manufacturing quality. Analysis of 204 clinical CAR T-cell products revealed that transduction efficiency is shaped primarily by manufacturing workflows and protocol-dependent starting material composition. Higher transduction efficiency was associated with early memory-like cellular states, providing insights into optimizing CAR T-cell.