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Received — 24 July 2025 ⏭ Most Recent Articles: Clinical Epigenetics

Monitoring breast cancer progression through circulating methylated GCM2 and TMEM240 detection

Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer-related deaths in women worldwide. Approximately 20–30% of women diagnosed with early-stage breast cancer eventually d...

DNA methylation in normal-appearing tissue associated with prostate cancer recurrence and metastasis

There is a need for more precise biomarkers and understanding on the development of aggressive prostate cancer. In this study, we analyzed DNA methylation in 64 prostate cancer tissue samples, using tissue fro...
Received — 22 July 2025 ⏭ Most Recent Articles: Clinical Epigenetics

Multifaceted regulation of the HOX cluster and its implications in oral cancer

The hypothesis that aberrant expression of homeobox (HOX) transcription factors contributes to oral cancer progression is gaining prominence. However, the mechanism of regulation involved in the clustered dysr...
Received — 17 July 2025 ⏭ Most Recent Articles: Clinical Epigenetics

RASGEF1C methylation for the distinguishment and classification of benign and malignant thyroid tumors

The incidence of thyroid cancer (TC) has significantly increased, highlighting the need for effective and objective approaches for the early diagnosis of TC. This study aimed to explore RASGEF1C methylation as a ...
Received — 14 July 2025 ⏭ Most Recent Articles: Clinical Epigenetics

Insulin levels at 18–20 gestational weeks in pregnant women with obesity are associated with newborn abdominal fat deposition and DNA methylation in cord blood

We assessed if fasting plasma insulin levels in pregnant women with obesity are associated with newborns’ abdominal fat deposition (dual-energy X-ray absorptiometry) and with cord blood DNA methylation (450k a...

Multiple highly methylated CpG sites as potential epigenetic markers for the diagnosis of prostate cancer

Prostate cancer (PCa) remains the leading cause of cancer deaths in men. The prostate-specific antigen (PSA) test is widely used for PCa screening, but it lacks specificity and can lead to over-diagnosis and o...
Received — 10 July 2025 ⏭ Most Recent Articles: Clinical Epigenetics

Clinical performance evaluation of a plasma dual-target methylation test for the detection of primary liver cancer: a multicenter study

Primary liver cancer (PLC) is a global health concern. The plasma dual-target methylation (PDTM) test, which interrogates the methylation status of GNB4 and Riplet, exhibits a commendable ability to discriminate ...
Received — 17 June 2025 ⏭ Most Recent Articles: Clinical Epigenetics

Association between pace of biological aging and cancer and the modulating role of physical activity: a national cross-sectional study

Cancer remains a serious public health problem impeding gains in life expectancy. Epigenetic clocks, derived from sets of DNA methylation CpGs and mathematical algorithms, have demonstrated a remarkable abilit...
Received — 15 June 2025 ⏭ Most Recent Articles: Clinical Epigenetics

A multi-omics and mediation-based genetic screening approach identifies STX4 as a key link between epigenetic regulation, immune cells, and childhood asthma

Childhood asthma presents a multifaceted immune-driven pathology shaped by genetic, epigenetic, and immune regulatory interactions. Despite extensive genome-wide analyses pinpointing multiple susceptibility lo...
Received — 28 April 2025 ⏭ Most Recent Articles: Clinical Epigenetics

Applying blood-derived epigenetic algorithms to saliva: cross-tissue similarity of DNA-methylation indices of aging, physiology, and cognition

Epigenetic algorithms of aging, health, and cognition, based on DNA-methylation (DNAm) patterns, are prominent tools for measuring biological age and have been linked to age-related diseases, cognitive decline...
Received — 13 April 2025 ⏭ Most Recent Articles: Clinical Epigenetics

Cross-sectional and longitudinal association of seven DNAm-based predictors with metabolic syndrome and type 2 diabetes

To date, various epigenetic clocks have been constructed to estimate biological age, most commonly using DNA methylation (DNAm). These include “first-generation” clocks such as DNAmAgeHorvath and “second-gener...
Received — 17 March 2025 ⏭ Most Recent Articles: Clinical Epigenetics

Epigenetic regulatory protein chromobox family regulates multiple signalling pathways and mechanisms in cancer

Signal transduction plays a pivotal role in modulating a myriad of critical processes, including the tumour microenvironment (TME), cell cycle arrest, proliferation and apoptosis of tumour cells, as well as th...
Received — 27 February 2025 ⏭ Most Recent Articles: Clinical Epigenetics

Imaging and outcome correlates of ctDNA methylation markers in prostate cancer: a comparative, cross-sectional [⁶⁸Ga]Ga-PSMA-11 PET/CT study

To validate the clinical utility of a previously identified circulating tumor DNA methylation marker (meth-ctDNA) panel for disease detection and survival outcomes, meth-ctDNA markers were compared to PSA leve...
Received — 31 December 2024 ⏭ Most Recent Articles: Clinical Epigenetics
Received — 24 December 2024 ⏭ Most Recent Articles: Clinical Epigenetics

Lactylation: the novel histone modification influence on gene expression, protein function, and disease

Lactic acid, traditionally considered as a metabolic waste product arising from glycolysis, has undergone a resurgence in scientific interest since the discovery of the Warburg effect in tumor cells. Numerous ...

DNA methylation and type 2 diabetes: a systematic review

DNA methylation influences gene expression and function in the pathophysiology of type 2 diabetes mellitus (T2DM). Mapping of T2DM-associated DNA methylation could aid early detection and/or therapeutic treatm...

Genome- and epigenome-wide association studies identify susceptibility of CpG sites and regions for metabolic syndrome in a Korean population

While multiple studies have investigated the relationship between metabolic syndrome (MetS) and its related traits (fasting glucose, triglyceride, HDL cholesterol, blood pressure, waist circumference) and DNA ...
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