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Received — 21 November 2025 ⏭ Most Recent Articles: Clinical Epigenetics

WTAP regulates NCOA4-mediated ferroptosis via a YTHDF2-dependent mechanism in preeclampsia

Preeclampsia (PE) is a pregnancy-specific hypertensive disorder associated with placental dysfunction and oxidative stress. This study explored whether WTAP regulates ferroptosis in trophoblasts through m6A-depen...

Epigenetic alterations in obstructive sleep Apnea: a pooled analysis of DNA methylation profiles in humans and animal models

Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder characterized by recurrent episodes of intermittent hypoxia (IH) and sleep fragmentation. OSA is strongly associated with cardiometabolic morb...

Epigenome-wide profiling of trisomy 18 specific DNA methylation signatures in first-trimester chorionic villi

Trisomy 18 (T18, Edwards syndrome) is a lethal chromosomal disorder characterized by multiple congenital anomalies and high perinatal mortality. Although epigenetic alterations have been described in aneuploid...

HMGA1 drives EMT in obliterative bronchiolitis through epigenetic regulation of chromatin accessibility in pulmonary epithelial cells

Post-transplant obliterative bronchiolitis (OB) is a major cause of lung graft dysfunction and failure, with the epithelial–mesenchymal transition (EMT) process playing a pivotal role in driving extracellular ...

Hypermethylated USP44 deubiquitinates SENP2: a critical mechanism in esophageal cancer progression and a new target for intervention

Ubiquitin-specific proteases (USPs) play a critical role in the development of various cancers. The study aimed to elucidated the pathogenic molecular mechanisms and analyze its clinical significance in esopha...
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