The Drosophila whole male central nervous system connectome enables end-to-end analysis of sensorimotor circuits. Comparison with existing female datasets shows that brain-wide wiring differences between the sexes are concentrated in higher centers.

Tracing visual signals through the fly connectome provides a brain-wide view of visual organization, linking visual inputs to more than half of central-brain cell types through multisynaptic pathways. Estimates of the information available to each type generate testable hypotheses for thousands of physiologically uncharacterized cell types.