The Drosophila whole male central nervous system connectome enables end-to-end analysis of sensorimotor circuits. Comparison with existing female datasets shows that brain-wide wiring differences between the sexes are concentrated in higher centers.

The complete gustatory system and the full set of feeding motor neurons of adult Drosophila are mapped at synaptic resolution, enabling the identification of taste neuron types and their likely tastants and showing how valence-specific circuit motifs route taste to generate distinct feeding, neuroendocrine, and social outputs.