A redesigned cancer immunotherapy is showing striking early results after decades of disappointment with similar drugs. Researchers engineered a more powerful CD40 agonist antibody and changed how it’s delivered—injecting it directly into tumors instead of into the bloodstream. In a small clinical trial of 12 patients with metastatic cancers, six saw their tumors shrink and two experienced complete remission.

A new UCLA Health study suggests that long-term exposure to the pesticide chlorpyrifos may dramatically raise the risk of Parkinson’s disease. Researchers found that people living in areas with sustained exposure had more than 2.5 times the likelihood of developing the disorder. Lab experiments reinforced the finding: animals exposed to the chemical developed movement problems, lost dopamine-producing neurons, and showed the same toxic protein buildup seen in Parkinson’s patients.

A clinical trial found that listening to specially designed music with auditory beat stimulation can significantly reduce anxiety. Among several listening lengths tested, a 24-minute session delivered the biggest benefits, easing both mental and physical symptoms of anxiety. The results suggest there may be an ideal “dose” of therapeutic music that works quickly without requiring long listening sessions.

New research shows that sourdough fermentation does more than make bread rise—it transforms wheat fibers in unexpected ways. Scientists found that enzymes already present in wheat, activated by the sourdough’s acidic environment, break down key fibres called arabinoxylans. This process may influence the bread’s texture, digestibility, and flavor. Some microbes even create buttery or subtly sweet notes that give sourdough its distinctive taste.

The distinctive smell of ancient mummies is helping scientists decode the secrets of Egyptian mummification. By analyzing tiny traces of chemicals in the air around mummy samples, researchers identified dozens of compounds linked to oils, resins, beeswax, and bitumen used during embalming. The chemical clues reveal that mummification grew increasingly complex over thousands of years.

Physicists at UC Santa Barbara have uncovered a new way to manipulate unusual magnetic states by exploiting “frustration” inside a crystal’s atomic structure. The team discovered a rare system where two different kinds of frustration—magnetic and electronic bond frustration—coexist and interact. By coupling these competing effects, researchers may be able to control exotic quantum states, potentially unlocking new ways to manipulate entangled spins for future quantum technologies.

Scientists have developed a powerful new computational method that could accelerate the search for next-generation materials capable of turning sunlight into useful chemical energy. The work focuses on polyheptazine imides, a promising class of carbon nitride materials that absorb visible light and can drive reactions such as hydrogen production, carbon dioxide conversion, and hydrogen peroxide synthesis. By analyzing how 53 different metal ions influence the structure and electronic behavior of these materials, researchers created a framework that predicts which combinations will perform best.

Scientists have discovered that cells can sense far beyond the surfaces they touch. While individual cancer cells can probe about 10 microns ahead by tugging on surrounding collagen fibers, clusters of normal epithelial cells can combine forces to detect layers as far as 100 microns away. This long-range “depth sensing” helps cells decide where to migrate. Understanding how it works could reveal new targets to stop cancer from spreading.

Researchers have developed a tiny antibody that can find a common cancer protein and make tumors light up during PET scans. In tests with mice, tumors containing the protein EphA2 glowed clearly when the antibody was used. This could help doctors quickly identify patients who may benefit from new targeted cancer treatments. The method may also provide a faster and less invasive alternative to traditional testing.

Scientists at MIT have discovered that a little-known protein called intelectin-2 plays a powerful double role in defending the gut. The protein strengthens the mucus layer that lines the gastrointestinal tract while also trapping and disabling harmful bacteria that try to break through. By binding to sugars on both mucus molecules and bacterial surfaces, intelectin-2 forms a protective barrier and can even destroy microbes, including some that resist antibiotics.

Artificial intelligence is often portrayed as a tool that replaces human work, but new research from Swansea University suggests a far more exciting role: creative collaborator. In a large study with more than 800 participants designing virtual cars, researchers found that AI-generated design galleries sparked deeper engagement, longer exploration, and better results.

A new AI framework called THOR is transforming how scientists calculate the behavior of atoms inside materials. Instead of relying on slow simulations that take weeks of supercomputer time, the system uses tensor network mathematics and machine-learning models to solve the problem directly. The approach can compute key thermodynamic properties hundreds of times faster while preserving accuracy. Researchers say this could accelerate discoveries in materials science, physics, and chemistry.

A new detection method called “Jerk” could dramatically improve how scientists forecast volcanic eruptions. By using a single broadband seismometer, the system can detect extremely subtle ground movements caused by magma pushing underground—often hours before an eruption begins. Tested for more than a decade at the Piton de la Fournaise volcano on La Réunion, the tool successfully predicted 92% of eruptions between 2014 and 2023, sometimes giving up to eight hours of warning.

Melatonin is now widely used to help children sleep, but scientists say the enthusiasm may be getting ahead of the evidence. A major review found clear benefits for children with conditions like autism and ADHD, yet far less data exists for typical childhood insomnia. Researchers also warn about mislabeled supplement doses and rising accidental ingestions among young kids. Experts say melatonin should be used carefully and only alongside proven behavioral sleep strategies.

Astronomers have discovered the brightest fast radio burst ever detected and traced it to a nearby galaxy using a new network of CHIME Outrigger telescopes. The flash, nicknamed RBFLOAT, lasted only a fraction of a second but briefly outshone every other radio source in its galaxy. Follow-up observations with the James Webb Space Telescope spotted a faint infrared signal at the same location. The burst’s unusual behavior—showing no signs of repeating—may challenge current ideas about what causes these mysterious cosmic flashes.

New research suggests Mars may have remained habitable much longer than scientists once thought. Ancient sand dunes in Gale Crater appear to have been soaked by underground water billions of years ago, leaving behind minerals that can preserve signs of life. Even after surface water disappeared, subsurface flows may have created protected environments for microbes. These hidden habitats could be key targets in the ongoing search for past life on Mars.

A major clinical trial has delivered an unexpected twist in the search for ways to fight COVID-19 and its lingering effects. Researchers at Mass General Brigham found that taking high doses of vitamin D3 did not make COVID-19 infections less severe or reduce hospital visits. However, the study uncovered a subtle but intriguing signal suggesting that people who consistently took vitamin D supplements might be slightly less likely to develop long COVID symptoms weeks after infection.

When the Asian financial crisis sent rice prices soaring in Indonesia in the late 1990s, the shock didn’t just strain household budgets—it left lasting marks on children’s bodies. Researchers from the University of Bonn found that kids exposed to the food price surge were more likely to experience stunted growth and, years later, a higher risk of obesity. The findings suggest that during crises, families often maintain calorie intake but cut back on nutrient-rich foods, creating hidden nutritional deficiencies that disrupt healthy development.

Scientists studying crops irrigated with treated wastewater discovered that trace pharmaceuticals often collect in plant leaves. Tomatoes, carrots, and lettuce absorbed medications such as antidepressants and seizure drugs during the experiment. However, the edible portions of tomatoes and carrots contained much lower levels than the leaves. The findings help researchers understand how crops process contaminants as wastewater reuse becomes more common.

A new study in mice suggests that a father’s nicotine exposure could influence the metabolic health of his children. Researchers found that when male mice consumed nicotine, their offspring showed changes in how their bodies handled sugar, including differences in insulin and glucose levels and altered liver function. These shifts may be linked to a higher risk of diabetes and related metabolic diseases.