Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11025-1
A generative committor-guided path-sampling framework reconstructs rare biomolecular transition pathways and reveals the underlying thermodynamics and kinetics without using predefined collective variables or brute-force sampling, at an acceptable computational cost.
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10876-y
In mice, a sparse population of sleep-active long-range inhibitory neurons in the neocortex promote widespread cortical synchronization and sleep, revealing a cortical mechanism that contributes to the regulation of sleep.
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10997-4
Evidence from Bianfu Cave shows specialized hunting, expedient stone-tool production and extensive bone use of Denisovans, providing new insights into their ecology, behaviour and cultural legacy in eastern Asia.
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10468-w
Eight integrated mutational footprints collectively explain the mutational processes in 85% of primary prostate cancer genomes.
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11003-7
A proximity-mapping atlas defines tumour-associated proximity antigens, revealing disease-associated membrane spatial communities, and identifies EGFR–CDCP1 as a co-target pair that enhances tumour killing by multispecific therapeutics.
Nature, Published online: 07 September 2026; doi:10.1038/s41586-026-11103-4
Author Correction: AhR inhibition promotes axon regeneration via a stress–growth switch
Nature, Published online: 26 May 2026; doi:10.1038/s41586-026-10669-3
Bottom-Up Synthesis of Molecular Nanodiamond from Nanographene
Nature, Published online: 21 May 2026; doi:10.1038/s41586-026-10656-8
De novo design of miniproteins targeting GPCRs
Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10565-w
By using singularity physics to enable cubic-root scaling of frequency and phase modulations induced by the Coriolis effect to enhance the performance of chip-scale Coriolis vibratory gyroscopes, substantial improvements in signal-to-noise ratio and precision are demonstrated.
Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10464-0
Researchers designed two-component proteins forming quasisymmetric cages via geometric frustration, enabling tunable virus-like assemblies for cargo delivery, cellular uptake and studying intracellular diffusion and protein localization.
Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10297-x
A drawing-like task designed to study compositional generalization identifies a specific neural population in the ventral premotor cortex in primates that encodes action symbols.
Nature, Published online: 20 May 2026; doi:10.1038/d41586-026-01327-9
In mice, motherhood induces transcriptional changes in the brain that endure beyond short-term hormonal shifts. Postpartum stress disrupts these patterns.
Nature, Published online: 19 May 2026; doi:10.1038/s41586-026-10658-6
An AI system to help scientists write expert-level empirical software
Nature, Published online: 19 May 2026; doi:10.1038/s41586-026-10644-y
Accelerating scientific discovery with Co-Scientist
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10519-2
Author Correction: HER2 expression identifies dynamic functional states within circulating breast cancer cells
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10362-5
Studies explaining the secondary Igk recombination mechanism are described and Cer/Sis deletion and/or displacement is implicated as a developmental switch converting the rearrangement mechanisms from two-loop-based diffusional primary Igk into one-loop-based linear scanning secondary mechanisms.
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10391-0
MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10377-y
A human spatial atlas of gene expression in liver based on live donors shows marked porto–central zonation of hepatocytes and non-parenchymal cells, and transcriptomic changes in early steatosis.
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10269-1
In this Perspective article, a theoretical framework for how the AP-1 family of transcription factors mediates cellular adaptation in cancer drug resistance is proposed.
Nature, Published online: 14 April 2026; doi:10.1038/s41586-026-10482-y
Autonomous closed-loop framework for reproducible perovskite solar cells
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