LoginAI and the human mind: only one is a black box
7 April 2026 at 08:00
Nature, Published online: 07 April 2026; doi:10.1038/d41586-026-01094-7
AI and the human mind: only one is a black boxNormal view
Received — 8 April 2026
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Nature - Issue - nature.com science feeds
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Nature - Issue - nature.com science feeds
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AI and the human mind: only one is a black box
Nature, Published online: 07 April 2026; doi:10.1038/d41586-026-01094-7AI and the human mind: only one is a black box
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Received — 2 April 2026
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Nature - Issue - nature.com science feeds
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DNA damage burden causes selective CUX2 neuron loss in neuroinflammation
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10310-3DNA damage burden and inadequate repair in CUX2+ cortical layer 2/3 excitatory neurons contributes to selective vulnerability in neuroinflammatory injury.
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DNA damage burden causes selective CUX2 neuron loss in neuroinflammation
1 April 2026 at 08:00
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10310-3
DNA damage burden and inadequate repair in CUX2+ cortical layer 2/3 excitatory neurons contributes to selective vulnerability in neuroinflammatory injury.-
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Developmental organization of sensory and sympathetic ganglia
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10313-0Findings suggest that neural crest fate bias predominantly emerges within the neural tube, and that only a minor subset of delaminated progenitors retain multipotency to generate both sensory and sympathetic derivatives.
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Developmental organization of sensory and sympathetic ganglia
1 April 2026 at 08:00
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10313-0
Findings suggest that neural crest fate bias predominantly emerges within the neural tube, and that only a minor subset of delaminated progenitors retain multipotency to generate both sensory and sympathetic derivatives.-
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A µ-opioid receptor superagonist analgesic with minimal adverse effects
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10299-9N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.
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A µ-opioid receptor superagonist analgesic with minimal adverse effects
1 April 2026 at 08:00
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10299-9
N-desethyl-fluornitrazene is a µ-opioid receptor agonist derived from nitazenes that has supramaximal intrinsic efficacy that produces analgesia with minimal adverse effects in rodent models.-
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Evidence of the pair-instability gap from black-hole masses
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10359-0LIGO–Virgo–KAGRA’s fourth Gravitational-Wave Transient Catalog shows evidence of a clear pair-instability gap in the distribution of binary black-hole secondary masses but is absent in the larger primary masses.
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Evidence of the pair-instability gap from black-hole masses
1 April 2026 at 08:00
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10359-0
LIGO–Virgo–KAGRA’s fourth Gravitational-Wave Transient Catalog shows evidence of a clear pair-instability gap in the distribution of binary black-hole secondary masses but is absent in the larger primary masses.-
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Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10290-4The transcription factor ATF4 is shown to regulate double-stranded DNA repair within vulnerable CUX2+ upper-layer 2/3 cortical neurons, enabling their survival during development.
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Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair
1 April 2026 at 08:00
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10290-4
The transcription factor ATF4 is shown to regulate double-stranded DNA repair within vulnerable CUX2+ upper-layer 2/3 cortical neurons, enabling their survival during development.-
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AhR inhibition promotes axon regeneration via a stress–growth switch
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10295-zAhR functions as a neuronal brake on axon regeneration, integrating environmental sensing, protein homeostasis and metabolic signalling to control the balance between stress adaptation and axonal repair.
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AhR inhibition promotes axon regeneration via a stress–growth switch
1 April 2026 at 08:00
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10295-z
AhR functions as a neuronal brake on axon regeneration, integrating environmental sensing, protein homeostasis and metabolic signalling to control the balance between stress adaptation and axonal repair.-
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Investigating the reproducibility of the social and behavioural sciences
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10203-5A study of reproducibility in a stratified random sample of 600 papers published from 2009 to 2018 in 62 journals spanning the social and behavioural sciences finds higher reproducibility among more recent papers and papers from journals that require data sharing.
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Investigating the reproducibility of the social and behavioural sciences
1 April 2026 at 08:00
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10203-5
A study of reproducibility in a stratified random sample of 600 papers published from 2009 to 2018 in 62 journals spanning the social and behavioural sciences finds higher reproducibility among more recent papers and papers from journals that require data sharing.-
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Evolution of pandemic cholera at its global source
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10340-xThe seventh cholera pandemic, driven by El Tor Vibrio cholerae, evolved separately in Bangladesh and India, with the Ganges Basin acting as the global source, and its evolution has been shaped by phage defence system changes, influencing severity and transmission.
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Evolution of pandemic cholera at its global source
1 April 2026 at 08:00
Nature, Published online: 01 April 2026; doi:10.1038/s41586-026-10340-x
The seventh cholera pandemic, driven by El Tor Vibrio cholerae, evolved separately in Bangladesh and India, with the Ganges Basin acting as the global source, and its evolution has been shaped by phage defence system changes, influencing severity and transmission.-
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Investigating the analytical robustness of the social and behavioural sciences
Nature, Published online: 01 April 2026; doi:10.1038/s41586-025-09844-9When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.
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Investigating the analytical robustness of the social and behavioural sciences
1 April 2026 at 08:00
Nature, Published online: 01 April 2026; doi:10.1038/s41586-025-09844-9
When 100 social and behavioural science claims were examined, 34% of reanalyses closely matched the original results, with 74% reaching the same conclusion, revealing limited robustness of single-path analyses and the need to address analytical uncertainty.-
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Huge meta-research project puts claims in social-science papers to the test
Nature, Published online: 01 April 2026; doi:10.1038/d41586-026-00805-4Three experts discuss lessons learnt from a large-scale dissection of the reproducibility, analytical robustness and replicability of published results.
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Huge meta-research project puts claims in social-science papers to the test
1 April 2026 at 08:00
Nature, Published online: 01 April 2026; doi:10.1038/d41586-026-00805-4
Three experts discuss lessons learnt from a large-scale dissection of the reproducibility, analytical robustness and replicability of published results.-
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See the intricate worlds of parasites and algae — March’s best science images
Nature, Published online: 31 March 2026; doi:10.1038/d41586-026-00901-5The month’s sharpest science shots, selected by Nature’s photo team.
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See the intricate worlds of parasites and algae — March’s best science images
31 March 2026 at 08:00
Nature, Published online: 31 March 2026; doi:10.1038/d41586-026-00901-5
The month’s sharpest science shots, selected by Nature’s photo team.
Received — 26 March 2026
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Nature - Issue - nature.com science feeds
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Genomic history of early dogs in Europe
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10112-7Genome-wide analysis shows European dogs existed by 14,200 years ago, were already genetically distinct, received less Neolithic Southwest Asian admixture than humans did and contributed substantially to later European dogs.
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Genomic history of early dogs in Europe
25 March 2026 at 08:00
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10112-7
Genome-wide analysis shows European dogs existed by 14,200 years ago, were already genetically distinct, received less Neolithic Southwest Asian admixture than humans did and contributed substantially to later European dogs.-
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Exposed phosphatidylserine is an inhibitory molecule in T cell exhaustion
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10266-4Insights into the mechanism by which phosphatidylserine functions as a non-classical inhibitory molecule during T cell exhaustion, and how phosphatidylserine-targeting antibodies enhance T cell responses are explored.
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Exposed phosphatidylserine is an inhibitory molecule in T cell exhaustion
25 March 2026 at 08:00
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10266-4
Insights into the mechanism by which phosphatidylserine functions as a non-classical inhibitory molecule during T cell exhaustion, and how phosphatidylserine-targeting antibodies enhance T cell responses are explored.-
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Aversive learning hijacks a brain sugar sensor to consolidate memory
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10306-zA study in Drosophilareveals a mechanism of non-homeostatic hunger and its critical relevance for memory consolidation.
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Aversive learning hijacks a brain sugar sensor to consolidate memory
25 March 2026 at 08:00
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10306-z
A study in Drosophilareveals a mechanism of non-homeostatic hunger and its critical relevance for memory consolidation.-
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A fast starburst wind consumes most of the energy from supernovae
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10231-1Starburst galaxies are seen to host galaxy-scale winds, which are super-fast and could be powered entirely by the thermal pressure of gas heated by supernovae.
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A fast starburst wind consumes most of the energy from supernovae
25 March 2026 at 08:00
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10231-1
Starburst galaxies are seen to host galaxy-scale winds, which are super-fast and could be powered entirely by the thermal pressure of gas heated by supernovae.-
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Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10264-6Androgen activity in the male embryonic hindbrain prolongs hindbrain differentiation in male individuals and drives sex differences in the incidence and prognosis of posterior fossa type A (PFA) ependymoma, an aggressive childhood brain tumour.
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Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma
25 March 2026 at 08:00
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10264-6
Androgen activity in the male embryonic hindbrain prolongs hindbrain differentiation in male individuals and drives sex differences in the incidence and prognosis of posterior fossa type A (PFA) ependymoma, an aggressive childhood brain tumour.-
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Rapid concerted switching of the neural code in the inferotemporal cortex
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10267-3Face cells in the macaque inferotemporal cortex are initially able to detect faces and then rapidly switch to a face-specific neural code to discriminate between different face identities.
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Rapid concerted switching of the neural code in the inferotemporal cortex
25 March 2026 at 08:00
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10267-3
Face cells in the macaque inferotemporal cortex are initially able to detect faces and then rapidly switch to a face-specific neural code to discriminate between different face identities.-
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Dogs were widely distributed across western Eurasia during the Palaeolithic
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10170-xAnalysis of nuclear and mitochondrial genomes from archaeological canid remains found across Europe and Anatolia shows that a genetically homogeneous dog population was already widely distributed across the region by 15,000 years ago.
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Dogs were widely distributed across western Eurasia during the Palaeolithic
25 March 2026 at 08:00
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10170-x
Analysis of nuclear and mitochondrial genomes from archaeological canid remains found across Europe and Anatolia shows that a genetically homogeneous dog population was already widely distributed across the region by 15,000 years ago.-
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Precipitation observing network gaps limit climate change impact assessment
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10300-5At present, only 13.4% of the global land surface meets the World Meteorological Organization requirements for annual precipitation monitoring.
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Precipitation observing network gaps limit climate change impact assessment
25 March 2026 at 08:00
Nature, Published online: 25 March 2026; doi:10.1038/s41586-026-10300-5
At present, only 13.4% of the global land surface meets the World Meteorological Organization requirements for annual precipitation monitoring.