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Received — 10 September 2026 ⏭ Nature - Issue - nature.com science feeds

Breaking timescales with generative sampling of conformational transitions

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11025-1

A generative committor-guided path-sampling framework reconstructs rare biomolecular transition pathways and reveals the underlying thermodynamics and kinetics without using predefined collective variables or brute-force sampling, at an acceptable computational cost.

Within-family effect of ancestry on complex traits in a Mexican population

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11039-9

This study uses a within-family design to identify significant ancestry differences in complex traits such as height and type 2 diabetes in a genetically diverse population from Mexico City.

Neocortical long-range inhibition promotes cortical synchrony and sleep

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10876-y

In mice, a sparse population of sleep-active long-range inhibitory neurons in the neocortex promote widespread cortical synchronization and sleep, revealing a cortical mechanism that contributes to the regulation of sleep.

An operational perturbation proteomics-based virtual cell model

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11001-9

Temporal protein-abundance measurements from systematically perturbed breast cancer cell lines were generated to develop ProteinTalks, a virtual cell model that functions as an operational tool for diverse drug discovery tasks.

Foaming photopolymers as a high-resolution biomimetic printing platform

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10968-9

Deep-foam photolithography uses light-controlled polymer foaming to create high-resolution, multifunctional microstructures with tunable optical, wetting and fluid-handling properties for advanced manufacturing applications.

Advancing conflict research and response through satellite-derived data

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11004-6

Integrating satellite-derived war-damage data with text-based fatality records through improvement, enrichment and fusion mitigates limitations inherent in each source, revealing complex violence dynamics beyond fatality-centric paradigms, as case studies from Ukraine and Myanmar illustrate.

Denisovans from southwestern China and their subsistence strategies

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10997-4

Evidence from Bianfu Cave shows specialized hunting, expedient stone-tool production and extensive bone use of Denisovans, providing new insights into their ecology, behaviour and cultural legacy in eastern Asia.

A serpin–myeloid axis in pancreatic cancer heterogeneity and immune evasion

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11002-8

SERPINE1 and SERPINB2-driven fibrin-rich niches locally programme immunosuppressive macrophages and exclude T cells, enabling spatially organized immune evasion in pancreatic ductal carcinoma.

Mobile education builds resilience during shocks in five countries

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10990-x

Remote phone-based targeted tutoring in five countries produced large, cost-effective learning gains during school closures, outperforming text messaging and working effectively when delivered by governments or non-governmental organizations to strengthen education resilience.

Ancient proteins identify various Denisovan remains from Southwest China

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10976-9

Identification and proteomic analysis of bone fragments and teeth from an excavation in Southwest China provide insight into the evolution and phenotype of Denisovans and fill a geographical gap in their documented distribution.

Predicting genome-wide functional constraints with GPN-Star

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11005-5

GPN-Star, a genomic language model with a phylogeny-aware architecture for whole-genome alignment data, is shown to be a scalable and flexible tool for genetic variant effect prediction across species.

Imaging cellular activity across all organs reveals body-wide circuits

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10979-6

An imaging system developed to record cellular activity throughout the whole body of zebrafish captures cellular organ dynamics and identifies multiple distributed circuits.

TRI-611, a selective, brain-penetrant molecular glue degrader of ALK

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10998-3

TRI-611 induces the degradation of ALK fusion proteins via a previously undescribed CRBN recruitment motif, and its preclinical anti-tumour activity highlights TRI-611 as a potential new way of treating ALK-positive non-small-cell lung cancer.

Anodic Pd membrane H<sub>2</sub> extraction enhances thermochemical dehydrogenation

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11008-2

An electrochemical cell with molten hydroxide and a Pd membrane actively extracts H2 and thereby boosts ammonia and methylcyclohexane conversion, while also delivering purified H2 ready for use.
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