Normal view

Received — 27 May 2026 ⏭ Nature - Issue - nature.com science feeds

Nature - Issue - nature.com science feeds
Emergence of oncofetal plasticity is ubiquitous in early colorectal cancers Julian R. Buissant des Amorie · Joris H. Hageman · Sascha R. Brunner · Suzanne E. M. van der Horst · Maria C. Puschhof · Arne van Hoeck · Inge van Lierop · Sjors Middelkamp · Lisa van der Schee · Sven van Kempen · Folkert Morsink · Robin Geene · Sander Mertens · David S. Cavigelli · Ingrid Verlaan-Klink · Lianne J. Kraaier · Jorieke Salij · Renate Bezemer · Onno Kranenburg · Miangela M. Laclé · Leon M. G. Moons · Hugo J. G. Snippert
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10344-7Metastasis-associated oncofetal cell states emerge at the earliest stages of colorectal cancer and spatial profiling shows stereotypic patterning of fibroblast subtypes resembling normal tissue architecture, resulting in distinct regional microenvironments that dictate the timing and positioning of oncofetal plasticity.
15 April 2026 at 08:00

Emergence of oncofetal plasticity is ubiquitous in early colorectal cancers

Nature - Issue - nature.com science feeds

15 April 2026 at 08:00

Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10344-7

Metastasis-associated oncofetal cell states emerge at the earliest stages of colorectal cancer and spatial profiling shows stereotypic patterning of fibroblast subtypes resembling normal tissue architecture, resulting in distinct regional microenvironments that dictate the timing and positioning of oncofetal plasticity.