LoginDe novo design of miniproteins targeting GPCRs
21 May 2026 at 08:00
Nature, Published online: 21 May 2026; doi:10.1038/s41586-026-10656-8
De novo design of miniproteins targeting GPCRsNormal view
Received — 27 May 2026
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Nature - Issue - nature.com science feeds
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Nature - Issue - nature.com science feeds
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De novo design of miniproteins targeting GPCRs
Nature, Published online: 21 May 2026; doi:10.1038/s41586-026-10656-8De novo design of miniproteins targeting GPCRs
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De novo design of quasisymmetric two-component protein cages
Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10464-0Researchers designed two-component proteins forming quasisymmetric cages via geometric frustration, enabling tunable virus-like assemblies for cargo delivery, cellular uptake and studying intracellular diffusion and protein localization.
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De novo design of quasisymmetric two-component protein cages
20 May 2026 at 08:00
Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10464-0
Researchers designed two-component proteins forming quasisymmetric cages via geometric frustration, enabling tunable virus-like assemblies for cargo delivery, cellular uptake and studying intracellular diffusion and protein localization.-
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Neural representation of action symbols in primate frontal cortex
Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10297-xA drawing-like task designed to study compositional generalization identifies a specific neural population in the ventral premotor cortex in primates that encodes action symbols.
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Neural representation of action symbols in primate frontal cortex
20 May 2026 at 08:00
Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10297-x
A drawing-like task designed to study compositional generalization identifies a specific neural population in the ventral premotor cortex in primates that encodes action symbols.-
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Forest carbon protocols underestimate climate-driven carbon loss risks
Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10571-yThe buffer pool designed to compensate for unintended carbon losses from the largest forest climate mitigation programme in the United States is too small when considering the impact of future climate change scenarios.
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Forest carbon protocols underestimate climate-driven carbon loss risks
20 May 2026 at 08:00
Nature, Published online: 20 May 2026; doi:10.1038/s41586-026-10571-y
The buffer pool designed to compensate for unintended carbon losses from the largest forest climate mitigation programme in the United States is too small when considering the impact of future climate change scenarios.-
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A multi-agent system for automating scientific discovery
Nature, Published online: 19 May 2026; doi:10.1038/s41586-026-10652-yA multi-agent system for automating scientific discovery
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A multi-agent system for automating scientific discovery
19 May 2026 at 08:00
Nature, Published online: 19 May 2026; doi:10.1038/s41586-026-10652-y
A multi-agent system for automating scientific discovery-
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Author Correction: HER2 expression identifies dynamic functional states within circulating breast cancer cells
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10519-2Author Correction: HER2 expression identifies dynamic functional states within circulating breast cancer cells
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Author Correction: HER2 expression identifies dynamic functional states within circulating breast cancer cells
15 April 2026 at 08:00
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10519-2
Author Correction: HER2 expression identifies dynamic functional states within circulating breast cancer cells-
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mRNA vaccines engage unconventional pathways in CD8<sup>+</sup> T cell priming
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10353-6mRNA–lipid-nanoparticle vaccines do not require type 1 conventional dendritic (cDC1) cells or the WDFY4-dependent cross-presentation pathway for CD8+ T cell priming but, instead, engage both cDC1 and cDC2 cells redundantly.
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mRNA vaccines engage unconventional pathways in CD8<sup>+</sup> T cell priming
15 April 2026 at 08:00
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10353-6
mRNA–lipid-nanoparticle vaccines do not require type 1 conventional dendritic (cDC1) cells or the WDFY4-dependent cross-presentation pathway for CD8+ T cell priming but, instead, engage both cDC1 and cDC2 cells redundantly.-
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Prospective evaluation of genomics-guided off-label treatment
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10405-xEvaluation by the Drug Rediscovery Protocol of off-label use of 37 approved cancer drugs on 1,610 patients showed modest activities overall, although subgroups of responders suggest that off-label drug use could be beneficial in tandem with more stringent biomarker selection.
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Prospective evaluation of genomics-guided off-label treatment
15 April 2026 at 08:00
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10405-x
Evaluation by the Drug Rediscovery Protocol of off-label use of 37 approved cancer drugs on 1,610 patients showed modest activities overall, although subgroups of responders suggest that off-label drug use could be beneficial in tandem with more stringent biomarker selection.-
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Cell-type-targeted mitochondrial transplantation rescues cell degeneration
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10391-0MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.
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Cell-type-targeted mitochondrial transplantation rescues cell degeneration
15 April 2026 at 08:00
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10391-0
MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.-
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Emergence of oncofetal plasticity is ubiquitous in early colorectal cancers
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10344-7Metastasis-associated oncofetal cell states emerge at the earliest stages of colorectal cancer and spatial profiling shows stereotypic patterning of fibroblast subtypes resembling normal tissue architecture, resulting in distinct regional microenvironments that dictate the timing and positioning of oncofetal plasticity.
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Emergence of oncofetal plasticity is ubiquitous in early colorectal cancers
15 April 2026 at 08:00
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10344-7
Metastasis-associated oncofetal cell states emerge at the earliest stages of colorectal cancer and spatial profiling shows stereotypic patterning of fibroblast subtypes resembling normal tissue architecture, resulting in distinct regional microenvironments that dictate the timing and positioning of oncofetal plasticity.-
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Therapeutic mitochondria transplants made more efficient with targeting tool
Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00910-4A system of protein binders directs energy-generating organelles to targeted cells, potentially improving ways to treat mitochondrial dysfunction.
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Therapeutic mitochondria transplants made more efficient with targeting tool
15 April 2026 at 08:00
Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00910-4
A system of protein binders directs energy-generating organelles to targeted cells, potentially improving ways to treat mitochondrial dysfunction.-
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Bad influence: LLMs can transmit malicious traits using hidden signals
Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00906-0A large language model that is trained using AI outputs can inherit undesirable behaviours, even if they are not directly referenced in the training data.
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Bad influence: LLMs can transmit malicious traits using hidden signals
15 April 2026 at 08:00
Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00906-0
A large language model that is trained using AI outputs can inherit undesirable behaviours, even if they are not directly referenced in the training data.-
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Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity
Nature, Published online: 14 April 2026; doi:10.1038/s41586-026-10493-9Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity
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Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity
14 April 2026 at 08:00
Nature, Published online: 14 April 2026; doi:10.1038/s41586-026-10493-9
Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity