Nature Biotechnology, Published online: 09 April 2026; doi:10.1038/s41587-026-03100-9
A tissue-engineered esophageal graft supports luminal patency in growing minipigs with emerging structural integration.
Nature Biotechnology, Published online: 08 April 2026; doi:10.1038/s41587-026-03087-3
Sequence Display maps protein variant activities to a sequencing-based readout.
Nature Biotechnology, Published online: 07 April 2026; doi:10.1038/s41587-026-03110-7
Progress toward a true virtual cell will depend on uniting AI’s pattern-finding power with the causal rigor of mechanistic models.
Nature Biotechnology, Published online: 07 April 2026; doi:10.1038/s41587-026-03092-6
A new class of agents is poised to transform treatment for people with narcolepsy by mimicking missing orexin peptides.
Nature Biotechnology, Published online: 01 April 2026; doi:10.1038/s41587-026-03051-1
ERAST speeds up homology search and provides a vector database for 1 billion biological sequences.
Nature Biotechnology, Published online: 31 March 2026; doi:10.1038/s41587-026-03068-6
Simultaneous profiling of adenylated and non-adenylated RNAs reveals regulatory programs across diverse cell types.
Nature Biotechnology, Published online: 31 March 2026; doi:10.1038/s41587-026-03083-7
Single-molecule 4Pi microscopy is simplified and made accessible by using a single objective.
Nature Biotechnology, Published online: 30 March 2026; doi:10.1038/s41587-026-03060-0
Non-transgenic crop improvement via cis-regulatory editing is limited by rare activating alleles and incomplete promoter maps. A massively parallel reporter assay in sorghum protoplasts quantifies more than 30,000 CRISPR-mimicking variants across three photosynthesis genes, finely mapping cis-regulatory modules and pinpointing compact edits that drive upregulated protein production.
Nature Biotechnology, Published online: 30 March 2026; doi:10.1038/s41587-026-03104-5
Immune cell engagers (ICEs) have emerged as a promising strategy for cancer immunotherapy, but their efficacy in solid tumors remains limited, partly as a result of the difficulty of coordinating activating and inhibitory signals within the same immune cell. Here, we report a logic-gated cis-targeting strategy that enables ICEs to coordinate activating and inhibitory signals within macrophages, thereby enhancing tumor clearance in mouse models of solid cancers.
Nature Biotechnology, Published online: 27 March 2026; doi:10.1038/s41587-026-03074-8
Unpaired data as a first-order challenge in single-cell and spatial proteomics
Nature Biotechnology, Published online: 27 March 2026; doi:10.1038/s41587-026-03046-y
Variant mapping of sorghum promoters identifies CRISPR-accessible mutations that upregulate gene expression.
Nature Biotechnology, Published online: 27 March 2026; doi:10.1038/s41587-026-03053-z
A long-read metagenome assembly method recovers circular and complete genomes better than existing tools.
Nature Biotechnology, Published online: 20 March 2026; doi:10.1038/s41587-026-03064-w
This Review discusses the promises and pitfalls of biological AI algorithms and presents a vision for generalist biological artificial intelligence, in which models can perform diverse tasks across biological domains.
Nature Biotechnology, Published online: 20 March 2026; doi:10.1038/s41587-026-03043-1
A tissue-engineered esophageal segment is functional in minipigs.
Nature Biotechnology, Published online: 18 March 2026; doi:10.1038/s41587-026-03055-x
An engineered Escherichia coli Nissle 1917 strain carrying a synthetic arginine–nitric oxide (NO) circuit enables sustained intratumoral NO production that promotes vascular normalization and immune reprogramming. This reshaped tumor microenvironment synergizes with blockade of the immune checkpoint PD-L1 to reinvigorate CD8+ T cells and drive durable tumor regression in mouse models.
Nature Biotechnology, Published online: 18 March 2026; doi:10.1038/s41587-026-03054-y
Solid tumors are sensitized to anti‑PD‑L1 immunotherapy by engineered E. coli to produce nitric oxide.
Nature Biotechnology, Published online: 18 March 2026; doi:10.1038/s41587-026-03061-z
Peptides are sequenced by converting each amino acid into amplifiable DNA barcodes.
Nature Biotechnology, Published online: 18 March 2026; doi:10.1038/s41587-026-03045-z
Base editor precision is increased by reverting established mutations.
Nature Biotechnology, Published online: 17 March 2026; doi:10.1038/s41587-026-03062-y
Balenciaga debuts eight-legged yarns
Nature Biotechnology, Published online: 17 March 2026; doi:10.1038/s41587-026-03067-7
FDA backpedals to review Moderna mRNA flu vaccine
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