Nature Biotechnology, Published online: 20 March 2026; doi:10.1038/s41587-026-03064-wThis Review discusses the promises and pitfalls of biological AI algorithms and presents a vision for generalist biological artificial intelligence, in which models can perform diverse tasks across biological domains.

Nature Biotechnology, Published online: 20 March 2026; doi:10.1038/s41587-026-03043-1A tissue-engineered esophageal segment is functional in minipigs.

Nature Biotechnology, Published online: 18 March 2026; doi:10.1038/s41587-026-03055-xAn engineered Escherichia coli Nissle 1917 strain carrying a synthetic arginine–nitric oxide (NO) circuit enables sustained intratumoral NO production that promotes vascular normalization and immune reprogramming. This reshaped tumor microenvironment synergizes with blockade of the immune checkpoint PD-L1 to reinvigorate CD8+ T cells and drive durable tumor regression in mouse models.

Nature Biotechnology, Published online: 18 March 2026; doi:10.1038/s41587-026-03054-ySolid tumors are sensitized to anti‑PD‑L1 immunotherapy by engineered E. coli to produce nitric oxide.

Nature Biotechnology, Published online: 18 March 2026; doi:10.1038/s41587-026-03061-zPeptides are sequenced by converting each amino acid into amplifiable DNA barcodes.

Nature Biotechnology, Published online: 18 March 2026; doi:10.1038/s41587-026-03045-zBase editor precision is increased by reverting established mutations.

Nature Biotechnology, Published online: 17 March 2026; doi:10.1038/s41587-026-03062-yBalenciaga debuts eight-legged yarns

Nature Biotechnology, Published online: 17 March 2026; doi:10.1038/s41587-026-03067-7FDA backpedals to review Moderna mRNA flu vaccine