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Received — 10 September 2026 ⏭ (Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)

(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)
Tumor Cell and Brain Microenvironment Interactions in Non-small Cell Lung Cancer Brain Metastasis: Mechanisms and Emerging Insights Heqi Yang · Qinghua Zhou
Zhongguo Fei Ai Za Zhi. 2026 Jul 20;29(7):548-556. doi: 10.3779/j.issn.1009-3419.2026.102.21.ABSTRACTBrain metastasis in non-small cell lung cancer (NSCLC) is shaped by continuous interactions between tumor cells and the brain-specific microenvironment. Vascular, glial and immune components contribute to intracranial colonization, immune escape and therapeutic resistance, while single-cell and spatial omics reveal heterogeneity in cellular states, communication networks and spatial niches. This
7 September 2026 at 18:00

Tumor Cell and Brain Microenvironment Interactions in Non-small Cell Lung Cancer Brain Metastasis: Mechanisms and Emerging Insights

(Multiomics OR Omics) AND (Lung OR gastric OR Hepatocellular)

By: Heqi Yang · Qinghua Zhou

7 September 2026 at 18:00

Zhongguo Fei Ai Za Zhi. 2026 Jul 20;29(7):548-556. doi: 10.3779/j.issn.1009-3419.2026.102.21.

ABSTRACT

Brain metastasis in non-small cell lung cancer (NSCLC) is shaped by continuous interactions between tumor cells and the brain-specific microenvironment. Vascular, glial and immune components contribute to intracranial colonization, immune escape and therapeutic resistance, while single-cell and spatial omics reveal heterogeneity in cellular states, communication networks and spatial niches. This review summarizes NSCLC brain metastasis and intracranial colonization, the brain metastatic microenvironment and tumor-microenvironment interactions, and discusses the heterogeneity revealed by single-cell and spatial omics and its potential relevance to therapeutic response and patient stratification. .

PMID:42705858 | DOI:10.3779/j.issn.1009-3419.2026.102.21