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Received — 13 September 2026 ⏭ Nature Medicine

Nature Medicine
Clinical usability of an explainable AI decision support tool and evaluation of multimodal models in NSCLC Arsela Prelaj · Vanja Miskovic · Matteo Sacco · Alberto Ferrarin · Cristina Maria Licciardello · Leonardo Provenzano · Margherita Favali · Ludovica Lerma · Aleksandra Zec · Andrea Spagnoletti · Monica Ganzinelli · Daniele Lorenzini · Beshoy Guirges · Luca Invernizzi · Cecilia Silvestri · Laura Mazzeo · Marco Meazza Prina · Giulia Corrao · Margherita Ruggirello · Andra Diana Dumitrascu · Rosa Maria Di Mauro · Dario Monzani · Gabriella Pravettoni · Michele Zanitti · Davide Macocchi · Moreno Bruno Marino · Chiara Cavalli · Rebecca Romanò · Claudia Giani · Samuel G. Armato III · Alessandra Esposito · Christine M. Bestvina · Maria Spector · Bogot R. Naama · Reham Basheer · Adi Lahiani Hafzadi · Laila Roisman · Iris Watermann · Marlen Szewczyk · Till Olchers · Heinz Richter · Constantin Blanke-Roeser · Costanza Siniscalchi · Anna Di Lello · Teresa Arangoa · Valentina Bartolomeo · Nikolaos Spathas · Evangelos Sarris · Elena Fountzilas · Aina Arbusà Roca · Rocio Caro-Consuegra · Patricia Iranzo · Melissa Fernández-Pinto · Jose Rodríguez-Morató · Luca Agnelli · Mari
Nature Medicine, Published online: 13 September 2026; doi:10.1038/s41591-026-04488-2In a large international real-world study of non-small cell lung cancer, a multimodal explainable AI model outperformed established biomarkers for immunotherapy outcome prediction and improved physician decision-making.
13 September 2026 at 08:00

Clinical usability of an explainable AI decision support tool and evaluation of multimodal models in NSCLC

By: Arsela Prelaj · Vanja Miskovic · Matteo Sacco · Alberto Ferrarin · Cristina Maria Licciardello · Leonardo Provenzano · Margherita Favali · Ludovica Lerma · Aleksandra Zec · Andrea Spagnoletti · Monica Ganzinelli · Daniele Lorenzini · Beshoy Guirges · Luca Invernizzi · Cecilia Silvestri · Laura Mazzeo · Marco Meazza Prina · Giulia Corrao · Margherita Ruggirello · Andra Diana Dumitrascu · Rosa Maria Di Mauro · Dario Monzani · Gabriella Pravettoni · Michele Zanitti · Davide Macocchi · Moreno Bruno Marino · Chiara Cavalli · Rebecca Romanò · Claudia Giani · Samuel G. Armato III · Alessandra Esposito · Christine M. Bestvina · Maria Spector · Bogot R. Naama · Reham Basheer · Adi Lahiani Hafzadi · Laila Roisman · Iris Watermann · Marlen Szewczyk · Till Olchers · Heinz Richter · Constantin Blanke-Roeser · Costanza Siniscalchi · Anna Di Lello · Teresa Arangoa · Valentina Bartolomeo · Nikolaos Spathas · Evangelos Sarris · Elena Fountzilas · Aina Arbusà Roca · Rocio Caro-Consuegra · Patricia Iranzo · Melissa Fernández-Pinto · Jose Rodríguez-Morató · Luca Agnelli · Mari

13 September 2026 at 08:00

Nature Medicine, Published online: 13 September 2026; doi:10.1038/s41591-026-04488-2

In a large international real-world study of non-small cell lung cancer, a multimodal explainable AI model outperformed established biomarkers for immunotherapy outcome prediction and improved physician decision-making.