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Received — 18 September 2026 ⏭ Nature Medicine

Nature Medicine
EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse Devin A. King · Shrishti Saxena · Danielle Caefer · Kyle C. Downer · Laura E. Saucier · Ethan Goodman · Jonmichael Aracena · Alena Zhirova · Anthilia Alchanat · Saoirse Nolan · Hrishikesh Lokhande · Howard L. Weiner · Benjamin E. Gewurz · Tanuja Chitnis
Nature Medicine, Published online: 16 September 2026; doi:10.1038/s41591-026-04665-3Increased expression of EBV reactivation genes in B cells and MS risk genes targeted by the EBV protein EBNA-2 precedes MS attacks, linking EBV reactivation and genetic risk to the development of MS relapses.
16 September 2026 at 08:00

EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse

By: Devin A. King · Shrishti Saxena · Danielle Caefer · Kyle C. Downer · Laura E. Saucier · Ethan Goodman · Jonmichael Aracena · Alena Zhirova · Anthilia Alchanat · Saoirse Nolan · Hrishikesh Lokhande · Howard L. Weiner · Benjamin E. Gewurz · Tanuja Chitnis

16 September 2026 at 08:00

Nature Medicine, Published online: 16 September 2026; doi:10.1038/s41591-026-04665-3

Increased expression of EBV reactivation genes in B cells and MS risk genes targeted by the EBV protein EBNA-2 precedes MS attacks, linking EBV reactivation and genetic risk to the development of MS relapses.