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Received — 4 April 2026 ⏭ Nature Medicine

Nature Medicine
Target product profiles for treatments to delay or prevent symptomatic Alzheimer’s disease Jeffrey L. Cummings · Michael G. Agadjanyan · Maureen Barry · Lawrence Corey · Rachelle Doody · Suzanne Hendrix · Soeren Mattke · Niklas Mattsson-Carlgren · Eric McDade · Joseph P. Menetski · Richard C. Mohs · Katherine A. Partrick · Nikolai Petrovsky · Dennis J. Selkoe · Diego Silva · Reisa A. Sperling · Benjamin Tiede · George Vradenburg
Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04305-wTo accelerate therapeutic development and equip stakeholders with clear benchmarks, the authors outline target product profiles for therapies designed to delay or prevent the onset of clinical symptoms of Alzheimer’s disease.
3 April 2026 at 08:00

Target product profiles for treatments to delay or prevent symptomatic Alzheimer’s disease

By: Jeffrey L. Cummings · Michael G. Agadjanyan · Maureen Barry · Lawrence Corey · Rachelle Doody · Suzanne Hendrix · Soeren Mattke · Niklas Mattsson-Carlgren · Eric McDade · Joseph P. Menetski · Richard C. Mohs · Katherine A. Partrick · Nikolai Petrovsky · Dennis J. Selkoe · Diego Silva · Reisa A. Sperling · Benjamin Tiede · George Vradenburg

3 April 2026 at 08:00

Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04305-w

To accelerate therapeutic development and equip stakeholders with clear benchmarks, the authors outline target product profiles for therapies designed to delay or prevent the onset of clinical symptoms of Alzheimer’s disease.

Received — 2 April 2026 ⏭ Nature Medicine

Nature Medicine
A deep joint-learning proteomics model for diagnosis of six conditions associated with dementia Lijun An · Alexa Pichet Binette · Ines Hristovska · Gabriele Vilkaite · Yu Xiao · Romina Zendehdel · Zijian Dong · Bart Smets · Rowan Saloner · Shinya Tasaki · Ying Xu · Varsha Krish · Farhad Imam · Shorena Janelidze · Danielle van Westen · Erik Stomrud · Christopher D. Whelan · Sebastian Palmqvist · Rik Ossenkoppele · Niklas Mattsson-Carlgren · Oskar Hansson · Jacob W. Vogel
Nature Medicine, Published online: 31 March 2026; doi:10.1038/s41591-026-04303-yProtAIDe-Dx is a deep joint-learning model that uses plasma proteomics to provide simultaneous probabilistic diagnoses across six conditions associated with aging.
31 March 2026 at 08:00

A deep joint-learning proteomics model for diagnosis of six conditions associated with dementia

Nature Medicine

By: Lijun An · Alexa Pichet Binette · Ines Hristovska · Gabriele Vilkaite · Yu Xiao · Romina Zendehdel · Zijian Dong · Bart Smets · Rowan Saloner · Shinya Tasaki · Ying Xu · Varsha Krish · Farhad Imam · Shorena Janelidze · Danielle van Westen · Erik Stomrud · Christopher D. Whelan · Sebastian Palmqvist · Rik Ossenkoppele · Niklas Mattsson-Carlgren · Oskar Hansson · Jacob W. Vogel

31 March 2026 at 08:00

Nature Medicine, Published online: 31 March 2026; doi:10.1038/s41591-026-04303-y

ProtAIDe-Dx is a deep joint-learning model that uses plasma proteomics to provide simultaneous probabilistic diagnoses across six conditions associated with aging.