Nature Medicine, Published online: 13 March 2026; doi:10.1038/s41591-026-04311-y
The field of genetic therapies needs robust investments, transparency and reliable regulatory frameworks to overcome recent challenges and continue to translate new technologies into patients’ benefit.
Nature Medicine, Published online: 13 March 2026; doi:10.1038/s41591-026-04310-z
Using global cancer incidence data from 185 countries, this study shows that four in ten cancers worldwide are attributable to modifiable risk factors. The findings highlight substantial opportunities for prevention through targeted, population-level interventions adapted to regional and sex-specific risk profiles.
Nature Medicine, Published online: 12 March 2026; doi:10.1038/s41591-026-04265-1
In this phase 1, open-label dose-escalation study in healthy adults found that the mRNA vaccine (mRNA-1215), encoding the Nipah virus Malaysian strain chimeric pre-fusion F protein linked to glycoprotein G, was safe and induced elevated immune responses at 1 year of follow-up, indicating that this is a promising vaccine candidate for further development.
Nature Medicine, Published online: 12 March 2026; doi:10.1038/s41591-026-04278-w
A real-world study showed that introducing a cognitive layer architecture to support specialized psychotherapeutic reasoning capabilities in general-purpose chatbots improved depression and anxiety symptoms compared to chatbots or therapists alone.
Nature Medicine, Published online: 12 March 2026; doi:10.1038/s41591-026-04252-6
The authors propose a framework for clinical AI evaluation within simulated digital hospital environments that capture the evolving constraints, and cascading effects, of clinical decisions.
Nature Medicine, Published online: 11 March 2026; doi:10.1038/s41591-026-04288-8
Author Correction: Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study
Nature Medicine, Published online: 11 March 2026; doi:10.1038/s41591-026-04272-2
Elevated serum levels of phosphorylated tau are not specific to Alzheimer’s disease and may also serve as a diagnostic tool for the most common types of systemic amyloidosis, with potential utility in distinguishing amyloidosis-related polyneuropathy from polyneuropathy of other etiologies.
Nature Medicine, Published online: 11 March 2026; doi:10.1038/s41591-026-04241-9
This Review highlights insights from recent clinical trials and discusses critical factors for optimizing cancer vaccines, with a focus on proxies for vaccine efficacy, neoantigen selection, modular platforms and early intervention.
Nature Medicine, Published online: 09 March 2026; doi:10.1038/s41591-026-04249-1
Data show that nutrient supplementation can modify epigenetic clock-based measurements of biological age, a major advance for the supplement field; however, whether such interventions can increase healthspan remains an open question.
Nature Medicine, Published online: 09 March 2026; doi:10.1038/s41591-026-04285-x
Three landmark trials confirm that fecal microbiota transplantation is a promising approach to enhancing immunotherapy efficacy in advanced solid tumors. The trials also provide insights with major implications for microbiome therapeutic development.
Nature Medicine, Published online: 09 March 2026; doi:10.1038/s41591-026-04239-3
In a prespecified ancillary analysis of the COSMOS randomized trial, supplementation with daily multivitamins, but not with cocoa extract, over the course of 2 years decreased biological aging, as measured by epigenetic aging clocks.
Nature Medicine, Published online: 09 March 2026; doi:10.1038/s41591-026-04237-5
WHO STEPS survey data help assess global physical activity inequalities, and inform a new framework to recognize the impact of physical activity on health beyond cardiometabolic disease.
Nature Medicine, Published online: 09 March 2026; doi:10.1038/d41591-026-00014-6
From chikungunya and dengue to yellow fever and Zika, mosquito‑transmitted diseases are spreading with urbanization, travel and climate change. A new generation of vaccines, trials and public‑health tools aim to keep ahead of the threat.
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