Nature Medicine, Published online: 25 March 2026; doi:10.1038/s41591-026-04296-8
Early clinical data on in vivo CAR-T cell therapy for multiple myeloma reveals key mechanistic insights and could mark the beginning of a new era of fast, streamlined and accessible immunotherapies.
Nature Medicine, Published online: 25 March 2026; doi:10.1038/s41591-025-04115-6
A blueprint to accelerate rare pediatric gene therapy approvals
Nature Medicine, Published online: 25 March 2026; doi:10.1038/s41591-026-04244-6
In a phase 1 trial, the in vivo generation of anti-BCMA CAR-T cells by lentiviral delivery was feasible and did not lead to dose-limiting toxicities in five patients with relapsed or refractory multiple myeloma.
Nature Medicine, Published online: 25 March 2026; doi:10.1038/s41591-026-04299-5
Results of the phase 2 POLAR trial show that biomarker-guided treatment in patients with metastatic pancreatic cancer based on homologous repair deficiency leads to encouraging clinical response rates in immune cell-infiltrated tumors.
Nature Medicine, Published online: 24 March 2026; doi:10.1038/s41591-026-04298-6
Local control, remote expertise: governing therapeutic telemedicine in wartime
Nature Medicine, Published online: 24 March 2026; doi:10.1038/d41591-026-00016-4
The small molecule rezatapopt binds a unique pocket in Y220C-mutant p53 and restores its tumor-suppressor function; a phase 1 study provides proof of concept of this therapeutic approach.
Nature Medicine, Published online: 24 March 2026; doi:10.1038/s41591-026-04262-4
The first-in-human clinical trial of the LRRK2-targeting antisense oligonucleotide BIIB094 in Parkinson’s disease demonstrates that the treatment is well tolerated and produces dose-dependent reductions in cerebrospinal fluid levels of LRRK2 and phosphorylated Rab10, indicating successful target engagement.
Nature Medicine, Published online: 24 March 2026; doi:10.1038/s41591-026-04253-5
In a large UK-based primary care randomized trial, immediate artificial intelligence (AI)-driven prioritization of chest X-rays did not significantly shorten time to computed tomography or lung cancer diagnosis versus standard workflow, suggesting that AI-based prioritization alone is unlikely to accelerate the lung cancer diagnostic pathway.
Nature Medicine, Published online: 16 March 2026; doi:10.1038/d41591-026-00015-5
A ‘universal vaccine’ administered intranasally provided mice broad protection against respiratory bacteria and viruses, paving the way for human studies.
Nature Medicine, Published online: 16 March 2026; doi:10.1038/s41591-026-04275-z
Artificial intelligence models are evolving from chats to hypotheses. Now their ideas are being validated in organoids and animals — and even in early-stage clinical trials.
Nature Medicine, Published online: 16 March 2026; doi:10.1038/s41591-026-04306-9
In cohort 4 of the ILUSTRO trial, combination of anti-CLDN18.2 zolbetuximab plus mFOLFOX6 and nivolumab in patients with CLDN18.2-positive, HER2-negative metastatic gastric or gastroesophageal junction adenocarcinoma led to encouraging clinical efficacy, supporting the testing of this combination in a phase 3 trial.
Nature Medicine, Published online: 13 March 2026; doi:10.1038/s41591-026-04311-y
The field of genetic therapies needs robust investments, transparency and reliable regulatory frameworks to overcome recent challenges and continue to translate new technologies into patients’ benefit.
Nature Medicine, Published online: 13 March 2026; doi:10.1038/s41591-026-04310-z
Using global cancer incidence data from 185 countries, this study shows that four in ten cancers worldwide are attributable to modifiable risk factors. The findings highlight substantial opportunities for prevention through targeted, population-level interventions adapted to regional and sex-specific risk profiles.
Nature Medicine, Published online: 12 March 2026; doi:10.1038/s41591-026-04265-1
In this phase 1, open-label dose-escalation study in healthy adults found that the mRNA vaccine (mRNA-1215), encoding the Nipah virus Malaysian strain chimeric pre-fusion F protein linked to glycoprotein G, was safe and induced elevated immune responses at 1 year of follow-up, indicating that this is a promising vaccine candidate for further development.
Nature Medicine, Published online: 12 March 2026; doi:10.1038/s41591-026-04278-w
A real-world study showed that introducing a cognitive layer architecture to support specialized psychotherapeutic reasoning capabilities in general-purpose chatbots improved depression and anxiety symptoms compared to chatbots or therapists alone.
Nature Medicine, Published online: 12 March 2026; doi:10.1038/s41591-026-04252-6
The authors propose a framework for clinical AI evaluation within simulated digital hospital environments that capture the evolving constraints, and cascading effects, of clinical decisions.
Nature Medicine, Published online: 11 March 2026; doi:10.1038/s41591-026-04288-8
Author Correction: Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study
Nature Medicine, Published online: 11 March 2026; doi:10.1038/s41591-026-04272-2
Elevated serum levels of phosphorylated tau are not specific to Alzheimer’s disease and may also serve as a diagnostic tool for the most common types of systemic amyloidosis, with potential utility in distinguishing amyloidosis-related polyneuropathy from polyneuropathy of other etiologies.
Nature Medicine, Published online: 11 March 2026; doi:10.1038/s41591-026-04241-9
This Review highlights insights from recent clinical trials and discusses critical factors for optimizing cancer vaccines, with a focus on proxies for vaccine efficacy, neoantigen selection, modular platforms and early intervention.
Nature Medicine, Published online: 09 March 2026; doi:10.1038/s41591-026-04249-1
Data show that nutrient supplementation can modify epigenetic clock-based measurements of biological age, a major advance for the supplement field; however, whether such interventions can increase healthspan remains an open question.
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