Nature Medicine, Published online: 26 May 2026; doi:10.1038/s41591-026-04401-x
Biobanks are introducing trusted research environments to enable secure data access, yet they can increase costs and complexity for biomedical researchers who use them. We discuss challenges and solutions and introduce the Python Phenofhy community tool for Our Future Health.
Nature Medicine, Published online: 26 May 2026; doi:10.1038/s41591-026-04376-9
In a multicenter phase 2 trial, the fibroblast growth factor receptor inhibitor rogaratinib showed encouraging clinical efficacy in patients with succinate dehydrogenase-deficient gastrointestinal stromal tumors, suggesting a potential new treatment option for this patient population and demonstrating that an epigenetic mechanism of oncogene activation can be successfully targeted with a tyrosine kinase inhibitor.
Nature Medicine, Published online: 22 May 2026; doi:10.1038/s41591-026-04456-w
Naming in medicine: how disease nomenclature shapes diagnosis, research and patient lives
Nature Medicine, Published online: 22 May 2026; doi:10.1038/d41591-026-00027-1
A rare case of genomic integration of an adenovirus vector led to a child developing a tumor — successfully removed by surgery — which highlights the importance of long-term safety monitoring in patients who receive gene therapy.
Nature Medicine, Published online: 22 May 2026; doi:10.1038/s41591-026-04416-4
At week 68, in patients who experienced poor weight loss following bariatric surgery, semaglutide was associated with 18.0% weight loss compared to 0.4% weight gain in patients receiving placebo.
Nature Medicine, Published online: 22 May 2026; doi:10.1038/s41591-026-04438-y
Will medical trainees who rely on AI fail to develop foundational independent clinical reasoning? This Perspective outlines a precautionary framework to preserve foundational competence while supporting safe and effective AI integration in medical training.
Nature Medicine, Published online: 21 May 2026; doi:10.1038/s41591-026-04413-7
Housing is not just a backdrop to health, but a powerful intervention. A study now shows that redesigning the home environment can improve child health outcomes, but success requires community co-design and solutions for cost and scalability.
Nature Medicine, Published online: 21 May 2026; doi:10.1038/s41591-026-04430-6
This Review surveys the fast-developing landscape of CAR T cells in autoimmune disease from both a technological and clinical standpoint, exploring the concept of deep B cell depletion and immune ‘reset’.
Nature Medicine, Published online: 07 April 2026; doi:10.1038/s41591-026-04307-8
In a phase 1 basket trial, the small interfering RNA zodasiran, targeting ANGPTL3, lowered triglycerides in patients with severe hypertriglyceridemia and lowered both triglycerides and low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolemia.
Nature Medicine, Published online: 06 April 2026; doi:10.1038/s41591-026-04282-0
In the phase 3 EMN24 IsKia trial, transplant-eligible patients with newly diagnosed multiple myeloma who received isatuximab with carfilzomib, lenalidomide and dexamethasone pretransplant induction and post-transplant consolidation showed higher rates of measurable residual disease negativity after consolidation than patients who received carfilzomib, lenalidomide and dexamethasone.
Nature Medicine, Published online: 06 April 2026; doi:10.1038/s41591-026-04287-9
Analysis of neuroimaging datasets across five major psychedelics revealed a shared brain signature and provides a comprehensive insight into how these drugs reorganize brain architecture.
Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04256-2
Whole-genome phylogenetic analyses have identified a case of monkeypox virus clade IIb lineage in the Republic of the Congo and co-circulation of three clade lineages, emphasizing the importance of improved surveillance given the risk of possible recombination events in the future.
Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04302-z
Exposome analyses across 34 countries showed that social exposures were associated with faster functional brain aging and physical exposures with faster structural brain aging.
Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04305-w
To accelerate therapeutic development and equip stakeholders with clear benchmarks, the authors outline target product profiles for therapies designed to delay or prevent the onset of clinical symptoms of Alzheimer’s disease.
Nature Medicine, Published online: 02 April 2026; doi:10.1038/s41591-026-04379-6
Author Correction: Real-world clinical utility of tumor whole-genome sequencing in solid cancers
Nature Medicine, Published online: 02 April 2026; doi:10.1038/s41591-026-04320-x
Quality health information for all is a fundamental determinant of health
Nature Medicine, Published online: 02 April 2026; doi:10.1038/s41591-026-04281-1
A prespecified analysis from the SELECT trial showed that semaglutide reduces major adverse cardiovascular events by 20% compared with placebo, particularly in patients at high risk of fibrosis, as indicated by the Fibrosis-4 index.
Nature Medicine, Published online: 01 April 2026; doi:10.1038/d41591-026-00019-1
After decades of stagnation, a renewed push in tuberculosis research is expanding the drug and vaccine pipeline to bring one of humanity’s oldest and deadliest infectious diseases under control.
Nature Medicine, Published online: 31 March 2026; doi:10.1038/s41591-026-04322-9
Nourishing people demands collaboration across sectors, political cycles and countries.
Nature Medicine, Published online: 31 March 2026; doi:10.1038/d41591-026-00018-2
In the phase 3 EVOKE(+) trials, semaglutide did not slow clinical progression of Alzheimer’s disease, but the findings provide new insights in the ongoing quest for treatments.
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