Nature Medicine, Published online: 09 September 2026; doi:10.1038/s41591-026-04678-y
Author Correction: Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance
Nature Medicine, Published online: 09 September 2026; doi:10.1038/s41591-026-04647-5
Consensus framework for the validation of generative AI: call for collaborators on the Validation Accords
Nature Medicine, Published online: 09 September 2026; doi:10.1038/s41591-026-04685-z
As the availability of clinical trial data continues to lag behind, other forms of evidence generation leveraging real-world data and citizen science need to be considered to improve women’s health.
Nature Medicine, Published online: 09 September 2026; doi:10.1038/s41591-026-04607-z
Following preclinical development, a randomized first-in-human trial showed that treatment with an inhaled, lung-epithelium-targeted siRNA directed against the receptor for advanced glycation end-products (RAGE) was safe and well tolerated and reduced RAGE levels in serum and bronchoalveolar lavage fluid.
Nature Medicine, Published online: 09 September 2026; doi:10.1038/s41591-026-04615-z
In a phase 2 randomized clinical trial, treatment with the myeloperoxidase (MPO) inhibitor mitiperstat, intended to target the neutrophil–MPO inflammatory pathway, did not improve symptoms or exercise function in individuals with heart failure with preserved or mildly reduced ejection fraction.
Nature Medicine, Published online: 08 September 2026; doi:10.1038/s41591-026-04641-x
A binding ban, and its limits: Japan legislates on heritable human genome editing
Nature Medicine, Published online: 07 September 2026; doi:10.1038/s41591-026-04633-x
The first generation of medical artificial intelligence (AI) was judged on whether algorithms could match clinicians. The next generation should be judged on whether carefully designed human–AI systems can improve patient outcomes.
Nature Medicine, Published online: 07 September 2026; doi:10.1038/s41591-026-04645-7
Strengthening clinical trial ethics and regulatory oversight in Africa: lessons from the TRACE initiative
Nature Medicine, Published online: 26 May 2026; doi:10.1038/s41591-026-04401-x
Biobanks are introducing trusted research environments to enable secure data access, yet they can increase costs and complexity for biomedical researchers who use them. We discuss challenges and solutions and introduce the Python Phenofhy community tool for Our Future Health.
Nature Medicine, Published online: 26 May 2026; doi:10.1038/s41591-026-04376-9
In a multicenter phase 2 trial, the fibroblast growth factor receptor inhibitor rogaratinib showed encouraging clinical efficacy in patients with succinate dehydrogenase-deficient gastrointestinal stromal tumors, suggesting a potential new treatment option for this patient population and demonstrating that an epigenetic mechanism of oncogene activation can be successfully targeted with a tyrosine kinase inhibitor.
Nature Medicine, Published online: 22 May 2026; doi:10.1038/s41591-026-04456-w
Naming in medicine: how disease nomenclature shapes diagnosis, research and patient lives
Nature Medicine, Published online: 22 May 2026; doi:10.1038/d41591-026-00027-1
A rare case of genomic integration of an adenovirus vector led to a child developing a tumor — successfully removed by surgery — which highlights the importance of long-term safety monitoring in patients who receive gene therapy.
Nature Medicine, Published online: 22 May 2026; doi:10.1038/s41591-026-04416-4
At week 68, in patients who experienced poor weight loss following bariatric surgery, semaglutide was associated with 18.0% weight loss compared to 0.4% weight gain in patients receiving placebo.
Nature Medicine, Published online: 22 May 2026; doi:10.1038/s41591-026-04438-y
Will medical trainees who rely on AI fail to develop foundational independent clinical reasoning? This Perspective outlines a precautionary framework to preserve foundational competence while supporting safe and effective AI integration in medical training.
Nature Medicine, Published online: 21 May 2026; doi:10.1038/s41591-026-04413-7
Housing is not just a backdrop to health, but a powerful intervention. A study now shows that redesigning the home environment can improve child health outcomes, but success requires community co-design and solutions for cost and scalability.
Nature Medicine, Published online: 21 May 2026; doi:10.1038/s41591-026-04430-6
This Review surveys the fast-developing landscape of CAR T cells in autoimmune disease from both a technological and clinical standpoint, exploring the concept of deep B cell depletion and immune ‘reset’.
Nature Medicine, Published online: 07 April 2026; doi:10.1038/s41591-026-04307-8
In a phase 1 basket trial, the small interfering RNA zodasiran, targeting ANGPTL3, lowered triglycerides in patients with severe hypertriglyceridemia and lowered both triglycerides and low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolemia.
Nature Medicine, Published online: 06 April 2026; doi:10.1038/s41591-026-04282-0
In the phase 3 EMN24 IsKia trial, transplant-eligible patients with newly diagnosed multiple myeloma who received isatuximab with carfilzomib, lenalidomide and dexamethasone pretransplant induction and post-transplant consolidation showed higher rates of measurable residual disease negativity after consolidation than patients who received carfilzomib, lenalidomide and dexamethasone.
Nature Medicine, Published online: 06 April 2026; doi:10.1038/s41591-026-04287-9
Analysis of neuroimaging datasets across five major psychedelics revealed a shared brain signature and provides a comprehensive insight into how these drugs reorganize brain architecture.
Nature Medicine, Published online: 03 April 2026; doi:10.1038/s41591-026-04256-2
Whole-genome phylogenetic analyses have identified a case of monkeypox virus clade IIb lineage in the Republic of the Congo and co-circulation of three clade lineages, emphasizing the importance of improved surveillance given the risk of possible recombination events in the future.
Login