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Received — 14 March 2026 ⏭ Nature Medicine

Nature Medicine
A clinical environment simulator for dynamic AI evaluation Luyang Luo · Sung Eun Kim · Xiaoman Zhang · Julius M. Kernbach · Roshan Kenia · Julian N. Acosta · Larry A. Nathanson · Adrian D. Haimovich · Adam Rodman · Ethan Goh · Jonathan H. Chen · Nigam H. Shah · David A. Kim · James Zou · Faisal Mahmood · Jakob Nikolas Kather · Matthew Lungren · Vivek Natarajan · Eric J. Topol · Pranav Rajpurkar
Nature Medicine, Published online: 12 March 2026; doi:10.1038/s41591-026-04252-6The authors propose a framework for clinical AI evaluation within simulated digital hospital environments that capture the evolving constraints, and cascading effects, of clinical decisions.
12 March 2026 at 08:00

A clinical environment simulator for dynamic AI evaluation

By: Luyang Luo · Sung Eun Kim · Xiaoman Zhang · Julius M. Kernbach · Roshan Kenia · Julian N. Acosta · Larry A. Nathanson · Adrian D. Haimovich · Adam Rodman · Ethan Goh · Jonathan H. Chen · Nigam H. Shah · David A. Kim · James Zou · Faisal Mahmood · Jakob Nikolas Kather · Matthew Lungren · Vivek Natarajan · Eric J. Topol · Pranav Rajpurkar

12 March 2026 at 08:00

Nature Medicine, Published online: 12 March 2026; doi:10.1038/s41591-026-04252-6

The authors propose a framework for clinical AI evaluation within simulated digital hospital environments that capture the evolving constraints, and cascading effects, of clinical decisions.