Nature Medicine, Published online: 09 March 2026; doi:10.1038/s41591-026-04249-1Data show that nutrient supplementation can modify epigenetic clock-based measurements of biological age, a major advance for the supplement field; however, whether such interventions can increase healthspan remains an open question.

Nature Medicine, Published online: 09 March 2026; doi:10.1038/s41591-026-04285-xThree landmark trials confirm that fecal microbiota transplantation is a promising approach to enhancing immunotherapy efficacy in advanced solid tumors. The trials also provide insights with major implications for microbiome therapeutic development.

Nature Medicine, Published online: 09 March 2026; doi:10.1038/s41591-026-04239-3In a prespecified ancillary analysis of the COSMOS randomized trial, supplementation with daily multivitamins, but not with cocoa extract, over the course of 2 years decreased biological aging, as measured by epigenetic aging clocks.

Nature Medicine, Published online: 09 March 2026; doi:10.1038/s41591-026-04237-5WHO STEPS survey data help assess global physical activity inequalities, and inform a new framework to recognize the impact of physical activity on health beyond cardiometabolic disease.

Nature Medicine, Published online: 09 March 2026; doi:10.1038/d41591-026-00014-6From chikungunya and dengue to yellow fever and Zika, mosquito‑transmitted diseases are spreading with urbanization, travel and climate change. A new generation of vaccines, trials and public‑health tools aim to keep ahead of the threat.