Nature Medicine, Published online: 13 March 2026; doi:10.1038/s41591-026-04311-yThe field of genetic therapies needs robust investments, transparency and reliable regulatory frameworks to overcome recent challenges and continue to translate new technologies into patients’ benefit.

Nature Medicine, Published online: 13 March 2026; doi:10.1038/s41591-026-04310-zUsing global cancer incidence data from 185 countries, this study shows that four in ten cancers worldwide are attributable to modifiable risk factors. The findings highlight substantial opportunities for prevention through targeted, population-level interventions adapted to regional and sex-specific risk profiles.

Nature Medicine, Published online: 12 March 2026; doi:10.1038/s41591-026-04265-1In this phase 1, open-label dose-escalation study in healthy adults found that the mRNA vaccine (mRNA-1215), encoding the Nipah virus Malaysian strain chimeric pre-fusion F protein linked to glycoprotein G, was safe and induced elevated immune responses at 1 year of follow-up, indicating that this is a promising vaccine candidate for further development.

Nature Medicine, Published online: 12 March 2026; doi:10.1038/s41591-026-04278-wA real-world study showed that introducing a cognitive layer architecture to support specialized psychotherapeutic reasoning capabilities in general-purpose chatbots improved depression and anxiety symptoms compared to chatbots or therapists alone.

Nature Medicine, Published online: 12 March 2026; doi:10.1038/s41591-026-04252-6The authors propose a framework for clinical AI evaluation within simulated digital hospital environments that capture the evolving constraints, and cascading effects, of clinical decisions.

Nature Medicine, Published online: 11 March 2026; doi:10.1038/s41591-026-04288-8Author Correction: Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study

Nature Medicine, Published online: 11 March 2026; doi:10.1038/s41591-026-04272-2Elevated serum levels of phosphorylated tau are not specific to Alzheimer’s disease and may also serve as a diagnostic tool for the most common types of systemic amyloidosis, with potential utility in distinguishing amyloidosis-related polyneuropathy from polyneuropathy of other etiologies.

Nature Medicine, Published online: 11 March 2026; doi:10.1038/s41591-026-04241-9This Review highlights insights from recent clinical trials and discusses critical factors for optimizing cancer vaccines, with a focus on proxies for vaccine efficacy, neoantigen selection, modular platforms and early intervention.