Nature Medicine, Published online: 26 May 2026; doi:10.1038/s41591-026-04401-xBiobanks are introducing trusted research environments to enable secure data access, yet they can increase costs and complexity for biomedical researchers who use them. We discuss challenges and solutions and introduce the Python Phenofhy community tool for Our Future Health.

Nature Medicine, Published online: 26 May 2026; doi:10.1038/s41591-026-04376-9In a multicenter phase 2 trial, the fibroblast growth factor receptor inhibitor rogaratinib showed encouraging clinical efficacy in patients with succinate dehydrogenase-deficient gastrointestinal stromal tumors, suggesting a potential new treatment option for this patient population and demonstrating that an epigenetic mechanism of oncogene activation can be successfully targeted with a tyrosine kinase inhibitor.

Nature Medicine, Published online: 22 May 2026; doi:10.1038/s41591-026-04456-wNaming in medicine: how disease nomenclature shapes diagnosis, research and patient lives

Nature Medicine, Published online: 22 May 2026; doi:10.1038/d41591-026-00027-1A rare case of genomic integration of an adenovirus vector led to a child developing a tumor — successfully removed by surgery — which highlights the importance of long-term safety monitoring in patients who receive gene therapy.

Nature Medicine, Published online: 22 May 2026; doi:10.1038/s41591-026-04416-4At week 68, in patients who experienced poor weight loss following bariatric surgery, semaglutide was associated with 18.0% weight loss compared to 0.4% weight gain in patients receiving placebo.

Nature Medicine, Published online: 22 May 2026; doi:10.1038/s41591-026-04438-yWill medical trainees who rely on AI fail to develop foundational independent clinical reasoning? This Perspective outlines a precautionary framework to preserve foundational competence while supporting safe and effective AI integration in medical training.

Nature Medicine, Published online: 21 May 2026; doi:10.1038/s41591-026-04413-7Housing is not just a backdrop to health, but a powerful intervention. A study now shows that redesigning the home environment can improve child health outcomes, but success requires community co-design and solutions for cost and scalability.

Nature Medicine, Published online: 21 May 2026; doi:10.1038/s41591-026-04430-6This Review surveys the fast-developing landscape of CAR T cells in autoimmune disease from both a technological and clinical standpoint, exploring the concept of deep B cell depletion and immune ‘reset’.