Nature Medicine, Published online: 13 September 2026; doi:10.1038/s41591-026-04587-0
A study shows that integrating numerous multimodal, patient-level biomarkers enhances the prediction of cancer immunotherapy response, but generalizability is still a challenge.
Nature Medicine, Published online: 13 September 2026; doi:10.1038/s41591-026-04488-2
In a large international real-world study of non-small cell lung cancer, a multimodal explainable AI model outperformed established biomarkers for immunotherapy outcome prediction and improved physician decision-making.
Nature Medicine, Published online: 11 September 2026; doi:10.1038/s41591-026-04621-1
The International Consortium of Digital Twins in Healthcare and Medicine was established to advance medical digital twin technology as a new infrastructure for precision health.
Nature Medicine, Published online: 11 September 2026; doi:10.1038/s41591-026-04642-w
In the randomized phase 2 ImmunoPRISM trial, patients with high-risk smoldering multiple myeloma (MM) showed higher rates of complete clinical responses in response to treatment with teclistamab compared with lenalidomide–dexamethasone, although longer follow-up is required to determine durable prevention of progression to MM.
Nature Medicine, Published online: 11 September 2026; doi:10.1038/s41591-026-04635-9
A 15-year cohort study shows that Alzheimer’s dementia risk is jointly shaped by Alzheimer’s pathology and cognitive resilience, with high resilience linked to lower risk, even under greater pathology.
Nature Medicine, Published online: 10 September 2026; doi:10.1038/s41591-026-04703-0
CRISP, a vision-based pathology foundation model developed exclusively from frozen section slides, supports treatment decision-making throughout the surgical workflow with superior performance to current foundation models and extensive validation, including in a prospective cohort.
Nature Medicine, Published online: 10 September 2026; doi:10.1038/s41591-026-04695-x
A suite of large pre-trained language models accurately extracts computable clinical data from unstructured electronic health records and integrates the findings into knowledge graphs that can facilitate understanding patient trajectories and treatment responses in the real world.
Nature Medicine, Published online: 10 September 2026; doi:10.1038/s41591-026-04596-z
An early assessment of the UK’s Our Future Health project shows how national-scale cohorts may reshape population medicine by accelerating discovery and clinical recruitment, provided that selection and phenotyping biases are carefully measured and managed.
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