npj Digital Medicine, Published online: 07 April 2026; doi:10.1038/s41746-026-02593-7

Lightweight liquid neural networks decipher salivary metabolic fingerprinting for high-risk periodontitis screening in diabetes

npj Digital Medicine, Published online: 07 April 2026; doi:10.1038/s41746-026-02605-6

Evaluation of artificial intelligence-generated vignettes depicting patient chatbot use in psychiatric contexts

npj Digital Medicine, Published online: 07 April 2026; doi:10.1038/s41746-026-02615-4

Yakdan et al. demonstrate that foundation models (FMs) trained to predict cervical spondylotic myelopathy from electronic health record data outperform traditional models on internal datasets but lose their advantage during external validation. This suggests that the feature-dense patterns learned by FMs may reduce their portability across settings, particularly for rare outcomes. As FMs approach clinical deployment, local validation, subgroup analysis, and attention to implementation burden are essential to inform health system planning and stewardship.

npj Digital Medicine, Published online: 07 April 2026; doi:10.1038/s41746-026-02470-3

Interpretable machine learning models for stroke risk prediction in patients with newly diagnosed atrial fibrillation

npj Digital Medicine, Published online: 06 April 2026; doi:10.1038/s41746-026-02600-x

Towards a physics informed digital twin to predict cerebral blood flow and cerebral vascular regulation

npj Digital Medicine, Published online: 06 April 2026; doi:10.1038/s41746-026-02525-5

Evaluating a digital serious game for learning medical terminology in a randomized controlled trial

npj Digital Medicine, Published online: 06 April 2026; doi:10.1038/s41746-026-02621-6

GenAI is increasingly used to draft replies to patient portal messages to reduce clinician workload. Evidence shows modest utilization and measurable workflow effects, alongside safety risks when clinicians miss errors or accept drafts with minimal editing. As deployments scale with deeper EHR integration and expanding transparency mandates, this Comment proposes governance that preserves efficiency without normalizing unsafe delegation: scoped use, risk tiering, accountable human authorship, auditability, and patient-facing transparency.

npj Digital Medicine, Published online: 04 April 2026; doi:10.1038/s41746-026-02586-6

Comparison of AI-generated radiology impressions: a multi-stakeholder evaluation

npj Digital Medicine, Published online: 04 April 2026; doi:10.1038/s41746-026-02596-4

Decipher-MR: a vision-language foundation model for 3D MRI representations

npj Digital Medicine, Published online: 04 April 2026; doi:10.1038/s41746-026-02599-1

Understanding digital health technology implementation in rehabilitation and development of the Rehabilitation Technologies Implementation model

npj Digital Medicine, Published online: 04 April 2026; doi:10.1038/s41746-026-02563-z

An operational target trial emulation framework for causal inference using electronic health record data

npj Digital Medicine, Published online: 04 April 2026; doi:10.1038/s41746-026-02594-6

A neural-symbolic AI agent system for biomedical concept mapping

npj Digital Medicine, Published online: 04 April 2026; doi:10.1038/s41746-026-02573-x

HoloTrauma 3X Triadic AI Co reasoning for robot assisted emergency maxillofacial reconstruction

npj Digital Medicine, Published online: 04 April 2026; doi:10.1038/s41746-026-02571-z

Developing psychosocial phenotypes to understand engagement with digital health technologies for heart failure

npj Digital Medicine, Published online: 04 April 2026; doi:10.1038/s41746-026-02584-8

We re-evaluated GPT-5 using our published pipelines: 500 emergency vignettes across 32 sociodemographic labels for bias, and adversarial prompts with fabricated details. GPT-5 showed no measurable improvement over GPT-4o in sociodemographic-linked decision variation, with several LGBTQIA+ groups flagged for mental-health screening in 100% of cases. Adversarial hallucination rates were higher (65% vs 53% for GPT-4o); a mitigation prompt reduced this to 7.67%.

npj Digital Medicine, Published online: 03 April 2026; doi:10.1038/s41746-026-02579-5

An AI-based mental health guardrail and dataset for identifying psychiatric crises in text-based conversations

npj Digital Medicine, Published online: 03 April 2026; doi:10.1038/s41746-026-02544-2

User-preference alignment with uncertainty-aware interactive rectification for liver organ and tumor segmentation and analysis from CT images

npj Digital Medicine, Published online: 03 April 2026; doi:10.1038/s41746-026-02557-x

Label-free pathological subtyping of non-small cell lung cancer using deep classification and virtual immunohistochemical staining

npj Digital Medicine, Published online: 03 April 2026; doi:10.1038/s41746-026-02512-w

Sensor-based digital health technologies to capture endpoints in recent clinical trials: a scoping review

npj Digital Medicine, Published online: 02 April 2026; doi:10.1038/s41746-026-02581-x

A robust vision language model for molecular status prediction and radiology report generation in adult-type diffuse gliomas