npj Digital Medicine, Published online: 11 April 2026; doi:10.1038/s41746-026-02602-9

Graphicalized vision-language modeling for comprehensive lung nodule analysis and risk stratification

npj Digital Medicine, Published online: 11 April 2026; doi:10.1038/s41746-026-02516-6

Application of machine learning in osteoporosis screening: a narrative review

npj Digital Medicine, Published online: 11 April 2026; doi:10.1038/s41746-026-02610-9

Cardiovascular digital twins using a Windkessel physics informed neural network

npj Digital Medicine, Published online: 11 April 2026; doi:10.1038/s41746-026-02601-w

Evaluating AI in leukocyte classification: performance of the AI system against 15 morphology experts

npj Digital Medicine, Published online: 11 April 2026; doi:10.1038/s41746-026-02578-6

Instant messaging-delivered brief motivational interviewing for noncommunicable disease patients with no intention to quit smoking

npj Digital Medicine, Published online: 10 April 2026; doi:10.1038/s41746-026-02614-5

Pursuit of biomarkers of brain diseases: beyond cohort comparisons

npj Digital Medicine, Published online: 10 April 2026; doi:10.1038/s41746-026-02609-2

The landscape of artificial intelligence-enabled medical devices in the EU and the US intended for intensive care units

npj Digital Medicine, Published online: 10 April 2026; doi:10.1038/s41746-026-02583-9

Predicting bilingual aphasia treatment outcomes using digital twins: a double-blind randomized controlled trial

npj Digital Medicine, Published online: 07 April 2026; doi:10.1038/s41746-026-02593-7

Lightweight liquid neural networks decipher salivary metabolic fingerprinting for high-risk periodontitis screening in diabetes

npj Digital Medicine, Published online: 07 April 2026; doi:10.1038/s41746-026-02605-6

Evaluation of artificial intelligence-generated vignettes depicting patient chatbot use in psychiatric contexts

npj Digital Medicine, Published online: 07 April 2026; doi:10.1038/s41746-026-02615-4

Yakdan et al. demonstrate that foundation models (FMs) trained to predict cervical spondylotic myelopathy from electronic health record data outperform traditional models on internal datasets but lose their advantage during external validation. This suggests that the feature-dense patterns learned by FMs may reduce their portability across settings, particularly for rare outcomes. As FMs approach clinical deployment, local validation, subgroup analysis, and attention to implementation burden are essential to inform health system planning and stewardship.

npj Digital Medicine, Published online: 07 April 2026; doi:10.1038/s41746-026-02470-3

Interpretable machine learning models for stroke risk prediction in patients with newly diagnosed atrial fibrillation

npj Digital Medicine, Published online: 06 April 2026; doi:10.1038/s41746-026-02600-x

Towards a physics informed digital twin to predict cerebral blood flow and cerebral vascular regulation

npj Digital Medicine, Published online: 06 April 2026; doi:10.1038/s41746-026-02525-5

Evaluating a digital serious game for learning medical terminology in a randomized controlled trial

npj Digital Medicine, Published online: 06 April 2026; doi:10.1038/s41746-026-02621-6

GenAI is increasingly used to draft replies to patient portal messages to reduce clinician workload. Evidence shows modest utilization and measurable workflow effects, alongside safety risks when clinicians miss errors or accept drafts with minimal editing. As deployments scale with deeper EHR integration and expanding transparency mandates, this Comment proposes governance that preserves efficiency without normalizing unsafe delegation: scoped use, risk tiering, accountable human authorship, auditability, and patient-facing transparency.

npj Digital Medicine, Published online: 04 April 2026; doi:10.1038/s41746-026-02586-6

Comparison of AI-generated radiology impressions: a multi-stakeholder evaluation

npj Digital Medicine, Published online: 04 April 2026; doi:10.1038/s41746-026-02596-4

Decipher-MR: a vision-language foundation model for 3D MRI representations

npj Digital Medicine, Published online: 04 April 2026; doi:10.1038/s41746-026-02599-1

Understanding digital health technology implementation in rehabilitation and development of the Rehabilitation Technologies Implementation model

npj Digital Medicine, Published online: 04 April 2026; doi:10.1038/s41746-026-02563-z

An operational target trial emulation framework for causal inference using electronic health record data

npj Digital Medicine, Published online: 04 April 2026; doi:10.1038/s41746-026-02594-6

A neural-symbolic AI agent system for biomedical concept mapping