This Viewpoint outlines implementation principles intended to protect individuals with medical frailty from unintended coverage disruption because of new policy under the budget reconciliation act of 2025 (HR 1).

This cross-sectional study uses Medicare data to compare 2 definitions of safety-net ambulatory practices to investigate the extent to which safety-net practices overlap.

This survey study investigates laypeople’s reactions to finding out that their clinician’s performance metrics may be based on the percentage of patients who undergo cancer screenings.

This cross-sectional study examines prior authorization processing times and approval rates for branded medication prescriptions that were initially rejected, and assesses key factors associated with variation in these outcomes.

This review evaluates the FDA Sentinel Initiative’s Active Risk Identification and Analysis system use and challenges amid ongoing plans to modernize it through the forthcoming Prescription Drug User Fee Act.

This Viewpoint proposes an expansion of state-run prescription-drug monitoring programs to meet the need for broader pharmacovigilance given the shift to alternative payment methods that bypass traditional insurance claims.

This JAMA Forum discusses the possibilities of using artificial intelligence to speed up the clinical trial process and accelerate the discovery and delivery of new treatments.