Normal view

Received — 27 May 2026 ⏭ Nature Cancer

Nature Cancer
Copper depletion boosts CNS leukemia therapy by inhibiting nucleotide synthesis through impairment of mitochondrial complex IV activity Alan Y. L. Wong · Jacob W. Myers · Gyan Prakash · Alice Ma · Jeannette R. Brook · Boryana Petrova · Baran Bulut · Ralph White III · Catherine Merz · Maeve de Souza · Adam G. Maynard · Peng Wang · Amy Yu · Nancy K. Pohl · Michal Weitman · Lewis B. Silverman · Kimberly Stegmaier · L. Stirling Churchman · Peter D. Cole · Donita C. Brady · Naama Kanarek
Nature Cancer, Published online: 25 May 2026; doi:10.1038/s43018-026-01177-4Wong et al. uncover a nutritional dependency for acute lymphoblastic leukemia cells that spread to the central nervous system and propose using copper restriction to impair leukemia progression by disrupting nucleotide synthesis through the inhibition of electron transport chain activity.
25 May 2026 at 08:00

Copper depletion boosts CNS leukemia therapy by inhibiting nucleotide synthesis through impairment of mitochondrial complex IV activity

By: Alan Y. L. Wong · Jacob W. Myers · Gyan Prakash · Alice Ma · Jeannette R. Brook · Boryana Petrova · Baran Bulut · Ralph White III · Catherine Merz · Maeve de Souza · Adam G. Maynard · Peng Wang · Amy Yu · Nancy K. Pohl · Michal Weitman · Lewis B. Silverman · Kimberly Stegmaier · L. Stirling Churchman · Peter D. Cole · Donita C. Brady · Naama Kanarek

25 May 2026 at 08:00

Nature Cancer, Published online: 25 May 2026; doi:10.1038/s43018-026-01177-4

Wong et al. uncover a nutritional dependency for acute lymphoblastic leukemia cells that spread to the central nervous system and propose using copper restriction to impair leukemia progression by disrupting nucleotide synthesis through the inhibition of electron transport chain activity.